Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

Valentina Escott-Price; Céline Bellenguez; Li-San Wang; Seung-Hoan Choi; Denise Harold; Lesley Jones; Peter Holmans; Amy Gerrish; Alexey Vedernikov; Alexander Richards; Anita L DeStefano; Jean-Charles Lambert; Carla A Ibrahim-Verbaas; Adam C Naj; Rebecca Sims; Gyungah Jun; Joshua C Bis; Gary W Beecham; Benjamin Grenier-Boley; Giancarlo Russo; Tricia A Thornton-Wells; Nicola Denning; Albert V Smith; Vincent Chouraki; Charlene Thomas; M Arfan Ikram; Diana Zelenika; Badri N Vardarajan; Yoichiro Kamatani; Chiao-Feng Lin; Helena Schmidt; Brian Kunkle; Melanie L Dunstan; Maria Vronskaya; Andrew D Johnson; Agustin Ruiz; Marie-Thérèse Bihoreau; Christiane Reitz; Florence Pasquier; Paul Hollingworth; Olivier Hanon; Annette L Fitzpatrick; Joseph D Buxbaum; Dominique Campion; Paul K Crane; Clinton Baldwin; Tim Becker; Vilmundur Gudnason; Carlos Cruchaga; David Craig; Najaf Amin; Claudine Berr; Oscar L Lopez; Philip L De Jager; Vincent Deramecourt; Janet A Johnston; Denis Evans; Simon Lovestone; Luc Letenneur; Isabel Hernández; David C Rubinsztein; Gudny Eiriksdottir; Kristel Sleegers; Alison M Goate; Nathalie Fiévet; Matthew J Huentelman; Michael Gill; Kristelle Brown; M Ilyas Kamboh; Lina Keller; Pascale Barberger-Gateau; Bernadette McGuinness; Eric B Larson; Amanda J Myers; Carole Dufouil; Stephen Todd; David Wallon; Seth Love; Ekaterina Rogaeva; John Gallacher; Peter St George-Hyslop; Jordi Clarimon; Alberto Lleo; Anthony Bayer; Debby W Tsuang; Lei Yu; Magda Tsolaki; Paola Bossù; Gianfranco Spalletta; Petra Proitsi; John Collinge; Sandro Sorbi; Florentino Sanchez Garcia; Nick C Fox; John Hardy; Maria Candida Deniz Naranjo; Paolo Bosco; Robert Clarke; Carol Brayne; Daniela Galimberti; Elio Scarpini; Ubaldo Bonuccelli; Michelangelo Mancuso; Gabriele Siciliano; Susanne Moebus; Patrizia Mecocci; Maria Del Zompo; Wolfgang Maier; Harald Hampel; Alberto Pilotto; Ana Frank-García; Francesco Panza; Vincenzo Solfrizzi; Paolo Caffarra; Benedetta Nacmias; William Perry; Manuel Mayhaus; Lars Lannfelt; Hakon Hakonarson; Sabrina Pichler; Minerva M Carrasquillo; Martin Ingelsson; Duane Beekly; Victoria Alvarez; Fanggeng Zou; Otto Valladares; Steven G Younkin; Eliecer Coto; Kara L Hamilton-Nelson; Cristina Razquin; Pau Pastor; Ignacio Mateo; Michael J Owen; Kelley M Faber; Palmi V Jonsson; Onofre Combarros; Michael C O'Donovan; Laura B Cantwell; Hilkka Soininen; Deborah Blacker; Simon Mead; Thomas H Mosley, Jr; David A Bennett; Tamara B Harris; Laura Fratiglioni; Clive Holmes; Renee F A G de Bruijn; Peter Passmore; Thomas J Montine; Karolien Bettens; Jerome I Rotter; Alexis Brice; Kevin Morgan; Tatiana M Foroud; Walter A Kukull; Didier Hannequin; John F Powell; Michael A Nalls; Karen Ritchie; Kathryn L Lunetta; John S K Kauwe; Eric Boerwinkle; Matthias Riemenschneider; Mercè Boada; Mikko Hiltunen; Eden R Martin; Reinhold Schmidt; Dan Rujescu; Jean-François Dartigues; Richard Mayeux; Christophe Tzourio; Albert Hofman; Markus M Nöthen; Caroline Graff; Bruce M Psaty; Jonathan L Haines; Mark Lathrop; Margaret A Pericak-Vance; Lenore J Launer; Christine Van Broeckhoven; Lindsay A Farrer; Cornelia M van Duijn; Alfredo Ramirez; Sudha Seshadri; Gerard D Schellenberg; Philippe Amouyel; Julie Williams

doi:10.1371/journal.pone.0094661

Back

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

Journal article

Open access

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Denise Harold, Lesley Jones, Peter Holmans, Amy Gerrish, Alexey Vedernikov, Alexander Richards, …

PloS one, Vol.9(6), pp.e94661-e94661

2014

DOI: https://doi.org/10.1371/journal.pone.0094661

PMCID: PMC4055488

PMID: 24922517

Appears in UM Open Access Research Published in PloS

Abstract

Carrier Proteins - genetics

Heat-Shock Proteins - genetics

Genome-Wide Association Study

Humans

Receptors, Antigen, B-Cell - genetics

Polymorphism, Single Nucleotide

Alzheimer Disease - genetics

Case-Control Studies

Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10-6) and 14 (IGHV1-67 p = 7.9×10-8) which indexed novel susceptibility loci. The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.

Files and links (1)

url

https://doi.org/10.1371/journal.pone.0094661View

Published (Version of record) Open

Metrics

13 Record Views

88 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.57 Alzheimer's Disease
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease
Creators: Valentina Escott-Price - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Céline Bellenguez - Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France
Li-San Wang - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
Seung-Hoan Choi - Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
Denise Harold - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Lesley Jones - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Peter Holmans - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Amy Gerrish - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Alexey Vedernikov - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Alexander Richards - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Anita L DeStefano - Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
Jean-Charles Lambert - Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France
Carla A Ibrahim-Verbaas - Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands
Adam C Naj - Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Rebecca Sims - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Gyungah Jun - Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Joshua C Bis - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America
Gary W Beecham - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America
Benjamin Grenier-Boley - Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France
Giancarlo Russo - Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland
Tricia A Thornton-Wells - Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America
Nicola Denning - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Albert V Smith - University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland
Vincent Chouraki - Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Charlene Thomas - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
M Arfan Ikram - Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands
Diana Zelenika - Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France
Badri N Vardarajan - Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America
Yoichiro Kamatani - Fondation Jean Dausset- CEPH, Paris, France
Chiao-Feng Lin - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
Helena Schmidt - Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
Brian Kunkle - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America
Melanie L Dunstan - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Maria Vronskaya - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Andrew D Johnson - NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts, United States of America
Agustin Ruiz - Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain
Marie-Thérèse Bihoreau - Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France
Christiane Reitz - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America
Florence Pasquier - Université Lille 2, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France
Paul Hollingworth - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Olivier Hanon - University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris, France
Annette L Fitzpatrick - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America; Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington, United States of America
Joseph D Buxbaum - Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America; Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
Dominique Campion - CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France
Paul K Crane - Department of Medicine, University of Washington, Seattle, Washington, United States of America
Clinton Baldwin - Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America
Tim Becker - German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Vilmundur Gudnason - University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland
Carlos Cruchaga - Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America
David Craig - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom
Najaf Amin - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands
Claudine Berr - INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France
Oscar L Lopez - Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Philip L De Jager - Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, United States of America
Vincent Deramecourt - Université Lille 2, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France
Janet A Johnston - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom
Denis Evans - Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America
Simon Lovestone - King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom
Luc Letenneur - Inserm U897, Victor Segalen University, F-33076, Bordeaux, France
Isabel Hernández - Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain
David C Rubinsztein - Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
Gudny Eiriksdottir - Icelandic Heart Association, Kopavogur, Iceland
Kristel Sleegers - Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
Alison M Goate - Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America
Nathalie Fiévet - Inserm U744, Lille, France; Institut Pasteur de Lille, Lille, France
Matthew J Huentelman - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America
Michael Gill - Discipline of Psychiatry, Trinity College, Dublin, Ireland
Kristelle Brown - Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom
M Ilyas Kamboh - Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Lina Keller - Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
Pascale Barberger-Gateau - King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom
Bernadette McGuinness - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom
Eric B Larson - Department of Medicine, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health, Seattle, Washington, United States of America
Amanda J Myers - Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
Carole Dufouil - Inserm U897, Victor Segalen University, F-33076, Bordeaux, France
Stephen Todd - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom
David Wallon - CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France
Seth Love - University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, United Kingdom
Ekaterina Rogaeva - Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada
John Gallacher - Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom
Peter St George-Hyslop - Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada; Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
Jordi Clarimon - Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
Alberto Lleo - Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
Anthony Bayer - Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom
Debby W Tsuang - Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America
Lei Yu - Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America
Magda Tsolaki - 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Paola Bossù - Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy
Gianfranco Spalletta - Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy
Petra Proitsi - King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom
John Collinge - MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom
Sandro Sorbi - NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy
Florentino Sanchez Garcia - Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain
Nick C Fox - Dementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom
John Hardy - Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom
Maria Candida Deniz Naranjo - Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain
Paolo Bosco - IRCCS Associazione Oasi Maria SS, Troina, Italy
Robert Clarke - Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
Carol Brayne - Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
Daniela Galimberti - University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy
Elio Scarpini - University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy
Ubaldo Bonuccelli - Neurological Clinic, University of Pisa, Pisa, Italy
Michelangelo Mancuso - Neurological Clinic, University of Pisa, Pisa, Italy
Gabriele Siciliano - Neurological Clinic, University of Pisa, Pisa, Italy
Susanne Moebus - Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
Patrizia Mecocci - Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Maria Del Zompo - Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
Wolfgang Maier - Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany
Harald Hampel - Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main, Germany (H.H.); Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany
Alberto Pilotto - Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy
Ana Frank-García - Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Instituto de Investigación Sanitaria "Hospital la Paz" (IdIPaz), Madrid, Spain
Francesco Panza - Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy
Vincenzo Solfrizzi - Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy
Paolo Caffarra - Department of Neuroscience-University of Parma, Parma, Italy; Center for Cognitive Disorders AUSL, Parma, Italy
Benedetta Nacmias - NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy
William Perry - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America
Manuel Mayhaus - Department Of Psychiatry, University Hospital, Saarland, Germany
Lars Lannfelt - Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden
Hakon Hakonarson - Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Sabrina Pichler - Department Of Psychiatry, University Hospital, Saarland, Germany
Minerva M Carrasquillo - Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
Martin Ingelsson - Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden
Duane Beekly - National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America
Victoria Alvarez - Genetica molecular-Huca-Oviedo, Oviedo, Spain
Fanggeng Zou - Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
Otto Valladares - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
Steven G Younkin - Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
Eliecer Coto - Genetica molecular-Huca-Oviedo, Oviedo, Spain
Kara L Hamilton-Nelson - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America
Cristina Razquin - Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain
Pau Pastor - Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain; CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain
Ignacio Mateo - Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain
Michael J Owen - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Kelley M Faber - Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America
Palmi V Jonsson - University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Landspitali University Hospital, Reykjavik, Iceland
Onofre Combarros - Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain
Michael C O'Donovan - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Laura B Cantwell - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
Hilkka Soininen - Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland
Deborah Blacker - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America
Simon Mead - MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom
Thomas H Mosley, Jr - Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America
David A Bennett - Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America
Tamara B Harris - Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America
Laura Fratiglioni - Aging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden
Clive Holmes - Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom
Renee F A G de Bruijn - Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands
Peter Passmore - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom
Thomas J Montine - Department of Pathology, University of Washington, Seattle, Washington, United States of America
Karolien Bettens - Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
Jerome I Rotter - Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America
Alexis Brice - INSERM UMR_S975-CNRS UMR 7225, Université Pierre et Marie Curie, Centre de recherche de l'Institut du Cerveau et de la Moëlle épinière-CRICM, Hôpital de la Salpêtrière, Paris France; AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France
Kevin Morgan - Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom
Tatiana M Foroud - Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America
Walter A Kukull - Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
Didier Hannequin - CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France
John F Powell - King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom
Michael A Nalls - Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
Karen Ritchie - INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Imperial College, London, United Kingdom
Kathryn L Lunetta - Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
John S K Kauwe - Department of Biology, Brigham Young University, Provo, Utah, United States of America
Eric Boerwinkle - Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America; Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America
Matthias Riemenschneider - Department of Psychiatry, University Hospital, Saarland, Germany
Mercè Boada - Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain; Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain
Mikko Hiltunen - Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland
Eden R Martin - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America
Reinhold Schmidt - Department of Neurology, Medical University Graz, Graz, Austria
Dan Rujescu - Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany
Jean-François Dartigues - Inserm U897, Victor Segalen University, F-33076, Bordeaux, France; Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France
Richard Mayeux - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America
Christophe Tzourio - Inserm U708, Victor Segalen University, Bordeaux, France
Albert Hofman - Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands
Markus M Nöthen - Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany
Caroline Graff - Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm, Sweden
Bruce M Psaty - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America
Jonathan L Haines - Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America
Mark Lathrop - Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Fondation Jean Dausset- CEPH, Paris, France; McGill University and Génome Québec Innovation Centre, Montreal, Canada
Margaret A Pericak-Vance - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America
Lenore J Launer - Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America
Christine Van Broeckhoven - Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
Lindsay A Farrer - Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Cornelia M van Duijn - Netherlands Consortium for Healthy Aging, Leiden, The Netherlands; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Center for Medical Systems Biology, Leiden, The Netherlands
Alfredo Ramirez - Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany
Sudha Seshadri - Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America; The Framingham Heart Study, Framingham, Massachusetts, United States of America
Gerard D Schellenberg - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
Philippe Amouyel - Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France; Centre Hospitalier Régional Universitaire de Lille, Lille, France
Julie Williams - Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
Publication Details: PloS one, Vol.9(6), pp.e94661-e94661
Publisher: United States
Grant note: P30 AG028377 / NIA NIH HHS P50 NS039764 / NINDS NIH HHS R01 AG027944 / NIA NIH HHS AG20098 / NIA NIH HHS U01 HG004402 / NHGRI NIH HHS U01 AG049505 / NIA NIH HHS R01 AG030146 / NIA NIH HHS R01 AG031287 / NIA NIH HHS P50 MH060451 / NIMH NIH HHS R01 AG034504 / NIA NIH HHS K24HL038444 / NHLBI NIH HHS P50 AG008702 / NIA NIH HHS P50 AG023501 / NIA NIH HHS R37 AG015473 / NIA NIH HHS P01 AG010491 / NIA NIH HHS P50 AG005681 / NIA NIH HHS R56 AG023629 / NIA NIH HHS P30 AG008017 / NIA NIH HHS R01 AG031581 / NIA NIH HHS HL087652 / NHLBI NIH HHS 164 / Alzheimer's Society R01 AG019085 / NIA NIH HHS R01 HL080295 / NHLBI NIH HHS P01 AG03991 / NIA NIH HHS R01 AG030653 / NIA NIH HHS AG027058 / NIA NIH HHS R01 AG041797 / NIA NIH HHS R01 AG021547 / NIA NIH HHS P50 AG016573 / NIA NIH HHS P01 AG019724 / NIA NIH HHS N01-AG-12100 / NIA NIH HHS K01 AG030514 / NIA NIH HHS R01 MH080295 / NIMH NIH HHS P50 AG005134 / NIA NIH HHS N01HC55022 / NHLBI NIH HHS P50 AG005128 / NIA NIH HHS P30 DK063491 / NIDDK NIH HHS R01 HL087652 / NHLBI NIH HHS Wellcome Trust U01 HL080295 / NHLBI NIH HHS MH60451 / NIMH NIH HHS MC_U137686857 / Medical Research Council N01HC85083 / NHLBI NIH HHS NS39764 / NINDS NIH HHS RF1 AG015819 / NIA NIH HHS R01 CA129769 / NCI NIH HHS AG08122 / NIA NIH HHS R01 AG023629 / NIA NIH HHS 167 / Alzheimer's Society N01HC55019 / NHLBI NIH HHS P30 AG010129 / NIA NIH HHS R01 AG020688 / NIA NIH HHS AG041718 / NIA NIH HHS R01 AG016495 / NIA NIH HHS HHSN268201200036C / NHLBI NIH HHS R01 AG026916 / NIA NIH HHS P50 AG005142 / NIA NIH HHS R01 AG015928 / NIA NIH HHS N01HC85082 / NHLBI NIH HHS R01 NS059873 / NINDS NIH HHS P30 AG010124 / NIA NIH HHS U24 AG026395 / NIA NIH HHS 100140 / Wellcome Trust U01 AG016976 / NIA NIH HHS U24 AG021886 / NIA NIH HHS R01 AG017917 / NIA NIH HHS P30 AG008051 / NIA NIH HHS 081864 / Wellcome Trust U01 AG032984 / NIA NIH HHS P50 AG016574 / NIA NIH HHS U01 AG006781 / NIA NIH HHS P50 AG008671 / NIA NIH HHS R01 AG019757 / NIA NIH HHS MC_U123192748 / Medical Research Council RC2 AG036528 / NIA NIH HHS N01HC85079 / NHLBI NIH HHS R01 AG041232 / NIA NIH HHS U01 HL096917 / NHLBI NIH HHS UC2 HL103 / NHLBI NIH HHS R01 AG041718 / NIA NIH HHS P50 AG005131 / NIA NIH HHS M01 RR000096 / NCRR NIH HHS P30 AG019610 / NIA NIH HHS AG033193 / NIA NIH HHS P01 AG002219 / NIA NIH HHS P50 AG005136 / NIA NIH HHS N01HC55018 / NHLBI NIH HHS U01 AG024904 / NIA NIH HHS UC2 HL103010 / NHLBI NIH HHS MR/L010305/1 / Medical Research Council MR/K013041/1 / Medical Research Council MR/L501517/1 / Medical Research Council RC2-HL102419 / NHLBI NIH HHS HL105756 / NHLBI NIH HHS AG021547 / NIA NIH HHS R56 AG020098 / NIA NIH HHS U01 HG006375 / NHGRI NIH HHS UL1 RR025005 / NCRR NIH HHS P50 AG005146 / NIA NIH HHS AG030653 / NIA NIH HHS R01 AG008122 / NIA NIH HHS N01HC55015 / NHLBI NIH HHS RC2 AG036535 / NIA NIH HHS P50 AG016582 / NIA NIH HHS R01 AG020098 / NIA NIH HHS N01HC25195 / NHLBI NIH HHS P50 AG016570 / NIA NIH HHS U01 HG004610 / NHGRI NIH HHS R01 HL096917 / NHLBI NIH HHS R01 AG033040 / NIA NIH HHS N01HC85081 / NHLBI NIH HHS P30 AG010161 / NIA NIH HHS P30 AG013854 / NIA NIH HHS AG027944 / NIA NIH HHS R01 HL093029 / NHLBI NIH HHS R01 AG017173 / NIA NIH HHS N01HC85086 / NHLBI NIH HHS N01HC55016 / NHLBI NIH HHS R01 AG015819 / NIA NIH HHS T32 GM008151 / NIGMS NIH HHS R01 NS017950 / NINDS NIH HHS AG034504 / NIA NIH HHS AG15928 / NIA NIH HHS MC_U123160651 / Medical Research Council R01 AG033193 / NIA NIH HHS P50 AG008671; / NIA NIH HHS AG010491 / NIA NIH HHS P50AG005133 / NIA NIH HHS N01HC85080 / NHLBI NIH HHS 095317 / Wellcome Trust AG019757 / NIA NIH HHS UL1 TR001108 / NCATS NIH HHS U01 AG010483 / NIA NIH HHS N01HC55021 / NHLBI NIH HHS 089703 / Wellcome Trust P30 AG028383 / NIA NIH HHS P30 AG012300 / NIA NIH HHS UL1 TR000124 / NCATS NIH HHS HL093029 / NHLBI NIH HHS RC2 HL102419 / NHLBI NIH HHS P30 AG010133 / NIA NIH HHS P50 AG005133 / NIA NIH HHS R01 AG027058 / NIA NIH HHS HHSN268200800007C / NHLBI NIH HHS N01HC55222 / NHLBI NIH HHS N01AG12100 / NIA NIH HHS U24 AG056270 / NIA NIH HHS P50 AG025688 / NIA NIH HHS P01 AG003991 / NIA NIH HHS P30 AG013846 / NIA NIH HHS R01 AG025259 / NIA NIH HHS R01 HL105756 / NHLBI NIH HHS P50 AG005138 / NIA NIH HHS N01HC55020 / NHLBI NIH HHS UL1 RR029893 / NCRR NIH HHS R01 AG037212 / NIA NIH HHS R01 HL087641 / NHLBI NIH HHS G0902227 / Medical Research Council HL080295 / NHLBI NIH HHS DK063491 / NIDDK NIH HHS AG023629 / NIA NIH HHS
Academic Unit: Cell Biology Research; John P. Hussman Institute for Human Genomics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation); Cell Biology Research; Miller School of Medicine; Miller School of Medicine; John P. Hussman Institute for Human Genomics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 24922517
PMCID: PMC4055488
Record Identifier: 991031561665402976