Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1

Wei Yu; Zhenwu Lin; John Hegarty; Xi Chen; Ashley Kelly; Yunhua Wang; Lisa Poritz; Walter Koltun

doi:10.1007/s10753-011-9390-9

Back

Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1

Journal article

Peer reviewed

Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1

Wei Yu, Zhenwu Lin, John Hegarty, Xi Chen, Ashley Kelly, Yunhua Wang, Lisa Poritz and Walter Koltun

Inflammation, Vol.35(3), pp.889-899

2012-06

DOI: https://doi.org/10.1007/s10753-011-9390-9

PMID: 21968973

Abstract

EGR1

Medicine & Public Health

cDNA microarray

Pharmacology/Toxicology

NKX2-3

Pathology

Gene Regulation

Rheumatology

Internal Medicine

Ulcerative colitis (UC) and Crohn’s disease (CD) are two related yet different forms of chronic intestinal inflammation. We investigated the genes regulated by NKX2-3 in B cells from a UC patient by cDNA microarray and compared the results to those genes regulated by NKX2-3 in B cells from a CD patient. Genes regulated by NKX2-3 in B cells from UC were mainly involved in cell growth, inflammation, and immune response. Among the genes regulated by NKX2-3 in both UC and CD, expression of 145 genes was similarly altered and 34 genes was differentially affected by NKX2-3 knockdown. EGR1 was up-regulated in NKX2-3 knockdown B cells from UC while down-regulated in NKX2-3 knockdown B cells from CD. mRNA expressions of NKX2-3 and EGR1 were increased in diseased intestinal tissues from 19 CD patients. NKX2-3 may play different roles in UC and CD pathogenesis by differential regulation of EGR1.

Metrics

6 Record Views

6 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.120 Inflammatory Bowel Diseases & Infections; 1.120.139 Ulcerative Colitis
Web Of Science research areas: Cell Biology; Immunology
ESI research areas: Immunology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1
Creators: Wei Yu - Department of Colon and Rectal Surgery Pennsylvania State University College of Medicine Hershey PA USA
Zhenwu Lin - Colon and Rectal Surgery, Mail code H137 The Milton S. Hershey Medical Center, Penn State College of Medicine 500 University Drive P.O. Box 850 Hershey PA 17033 USA
John Hegarty - Department of Colon and Rectal Surgery Pennsylvania State University College of Medicine Hershey PA USA
Xi Chen - Department of Biostatistics Vanderbilt University School of Medicine Nashville TN USA
Ashley Kelly - Department of Colon and Rectal Surgery Pennsylvania State University College of Medicine Hershey PA USA
Yunhua Wang - Department of Colon and Rectal Surgery Pennsylvania State University College of Medicine Hershey PA USA
Lisa Poritz - Department of Cellular and Molecular Physiology Pennsylvania State University College of Medicine Hershey PA USA
Walter Koltun - Colon and Rectal Surgery, Mail code H137 The Milton S. Hershey Medical Center, Penn State College of Medicine 500 University Drive P.O. Box 850 Hershey PA 17033 USA
Publication Details: Inflammation, Vol.35(3), pp.889-899
Publisher: Springer US
Academic Unit: Miller School of Medicine; UMMG Department of Public Health Sciences Research
Language: English
Resource Type: Journal article
PMID: 21968973
Record Identifier: 991031599149402976