Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Hong Lee; Stephan Ripke; Benjamin Neale; Stephen Faraone; Shaun Purcell; Roy Perlis; Bryan Mowry; Anita Thapar; Michael Goddard; John Witte; Devin Absher; Ingrid Agartz; Huda Akil; Farooq Amin; Ole Andreassen; Adebayo Anjorin; Richard Anney; Verneri Anttila; Dan Arking; Philip Asherson; Maria Azevedo; Lena Backlund; Judith Badner; Anthony Bailey; Tobias Banaschewski; Jack Barchas; Michael Barnes; Thomas Barrett; Nicholas Bass; Agatino Battaglia; Michael Bauer; Mònica Bayés; Frank Bellivier; Sarah Bergen; Wade Berrettini; Catalina Betancur; Thomas Bettecken; Joseph Biederman; Elisabeth Binder; Donald Black; Douglas Blackwood; Cinnamon Bloss; Michael Boehnke; Dorret Boomsma; Gerome Breen; René Breuer; Richard Bruggeman; Paul Cormican; Nancy Buccola; Jan Buitelaar; William Bunney; Joseph Buxbaum; William Byerley; Enda Byrne; Sian Caesar; Wiepke Cahn; Rita Cantor; Miguel Casas; Aravinda Chakravarti; Kimberly Chambert; Khalid Choudhury; Sven Cichon; Robert Cloninger; David Collier; Edwin Cook; Hilary Coon; Bru Cormand; Aiden Corvin; William Coryell; David Craig; Ian Craig; Jennifer Crosbie; Michael Cuccaro; David Curtis; Darina Czamara; Susmita Datta; Geraldine Dawson; Richard Day; Eco De Geus; Franziska Degenhardt; Srdjan Djurovic; Gary Donohoe; Alysa Doyle; Jubao Duan; Frank Dudbridge; Eftichia Duketis; Richard Ebstein; Howard Edenberg; Josephine Elia; Sean Ennis; Bruno Etain; Ayman Fanous; Anne Farmer; I Nicol Ferrier; Matthew Flickinger; Eric Fombonne; Tatiana Foroud; Josef Frank; Barbara Franke; Christine Fraser

doi:10.1038/ng.2711

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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Journal article

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Peer reviewed

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Hong Lee, Stephan Ripke, Benjamin Neale, Stephen Faraone, Shaun Purcell, Roy Perlis, Bryan Mowry, Anita Thapar, Michael Goddard, John Witte, …

Nature genetics, Vol.45(9), pp.984-94

2013-08-28

DOI: https://doi.org/10.1038/ng.2711

PMCID: PMC3800159

PMID: 23933821

Abstract

Life Sciences

Biochemistry, Molecular Biology

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.455 Genome-Wide Association Studies
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics

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Title: Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Creators: Hong Lee - Queensland Brain Institute
Stephan Ripke - Stanley Center for Psychiatric Research
Benjamin Neale - Analytic and Translational Genetics Unit
Stephen Faraone - Department of Psychiatry
Shaun Purcell - Stanley Center for Psychiatric Research
Roy Perlis - Stanley Center for Psychiatric Research
Bryan Mowry - Queensland Brain Institute
Anita Thapar - Institute of Psychological Medicine and Clinical Neurosciences
Michael Goddard - Faculty of Land and Environment
John Witte - Department of Epidemiology and Biostatistics
Devin Absher - HudsonAlpha Institute for Biotechnology
Ingrid Agartz - KG Jebsen Centre for Psychosis Research
Huda Akil - Molecular Psychiatry Laboratory
Farooq Amin - Department of Psychiatry and Behavioral Sciences
Ole Andreassen - KG Jebsen Centre for Psychosis Research
Adebayo Anjorin - Department of Psychiatry and Behavioral Sciences
Richard Anney - Department of Psychiatry
Verneri Anttila - Analytic and Translational Genetics Unit
Dan Arking - McKusick-Nathans Institute of Genetic Medicine
Philip Asherson - MRC Social, Genetic and Developmental Psychiatry Centre
Maria Azevedo - Institute for Biomedical Imaging and Life Science
Lena Backlund - Department of Psychiatry
Judith Badner - Department of Psychiatry
Anthony Bailey - Department of Psychiatry
Tobias Banaschewski - Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim]
Jack Barchas - Department of Psychiatry
Michael Barnes - Bioinformatics
Thomas Barrett - Internal Medicine
Nicholas Bass - Mental Health Sciences Unit
Agatino Battaglia - Department of Psychiatry and Behavioral Sciences [Stanford]
Michael Bauer - Department of Psychiatry and Psychotherapy
Mònica Bayés - Centro Nacional de Análisis Genómico
Frank Bellivier - Institut Mondor de Recherche Biomédicale
Sarah Bergen - Stanley Center for Psychiatric Research
Wade Berrettini - Department of Psychiatry [Philadelphia]
Catalina Betancur - Physiopathologie des Maladies du Système Nerveux Central
Thomas Bettecken - Center for Human Genetic Research
Joseph Biederman - Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD
Elisabeth Binder - Division Genetic Epidemiology in Psychiatry
Donald Black - Department of Psychiatry
Douglas Blackwood - Division of Psychiatry
Cinnamon Bloss - The Scripps Translational Science Institute and Scripps Health
Michael Boehnke - Department of Biostatistics and Center for Statistical Genetics
Dorret Boomsma - Genetic Epidemiology Unit
Gerome Breen - MRC Social, Genetic and Developmental Psychiatry Centre
René Breuer - Department of Genetic Epidemiology in Psychiatry [Mannhein]
Richard Bruggeman - Department of Psychiatry
Paul Cormican - Department of Psychiatry
Nancy Buccola - School of Nursing
Jan Buitelaar - Donders Center for Cognitive Neuroimaging
William Bunney - Department of Psychiatry and Human Behavior
Joseph Buxbaum - Friedman Brain Institute, Mount Sinai
William Byerley - Department of Psychiatry
Enda Byrne - Queensland Brain Institute
Sian Caesar - Department of Psychiatry, School of Clinical and Experimental Medicine
Wiepke Cahn - Department of Psychiatry
Rita Cantor - Department of Human Genetics, Los Angeles
Miguel Casas - Department of Psychiatry
Aravinda Chakravarti - McKusick-Nathans Institute of Genetic Medicine
Kimberly Chambert - Stanley Center for Psychiatric Research
Khalid Choudhury - Mental Health Sciences Unit
Sven Cichon - Department of Genomics, Life and Brain Center
Robert Cloninger - Department of Psychiatry
David Collier - MRC Social, Genetic and Developmental Psychiatry Centre
Edwin Cook - Department of Disability and Human Development
Hilary Coon - Department of Developmental Neuroscience
Bru Cormand - Department of Psychiatry
Aiden Corvin - Department of Psychiatry
William Coryell - Department of Psychiatry
David Craig - Department of Psychiatry
Ian Craig - MRC Social, Genetic and Developmental Psychiatry Centre
Jennifer Crosbie - Department of Psychiatry
Michael Cuccaro - John P. Hussman Institute for Human Genomics
David Curtis - East London NHS Foundation Trust
Darina Czamara - Max-Planck-Institut für Psychiatrie
Susmita Datta - Genetics Institute
Geraldine Dawson - Autism Speaks and the Department of Psychiatry
Richard Day - School of Neurology, Neurobiology and Psychiatry
Eco De Geus - Medstar Research Institute
Franziska Degenhardt - Department of Genomics, Life and Brain Center
Srdjan Djurovic - KG Jebsen Centre for Psychosis Research
Gary Donohoe - Department of Psychiatry
Alysa Doyle - Psychiatric and Neurodevelopmental Genetics Unit
Jubao Duan - Department of Psychiatry and Behavioral Sciences
Frank Dudbridge - Department of Non-Communicable Disease Epidemiology
Eftichia Duketis - Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
Richard Ebstein - Psychology Department
Howard Edenberg - Department of Biochemistry and Molecular Biology, Department of Medical and Molecular Genetics
Josephine Elia - Department of Psychiatry
Sean Ennis - Academic Centre on Rare Diseases
Bruno Etain - Institut Mondor de Recherche Biomédicale
Ayman Fanous - Virginia Institute of Psychiatric and Behavioral Genetics
Anne Farmer - MRC Social, Genetic and Developmental Psychiatry Centre
I Nicol Ferrier - University of Dundee School of Medicine
Matthew Flickinger - Department of Biostatistics and Center for Statistical Genetics
Eric Fombonne - Department of Child Psychiatry
Tatiana Foroud - Department of Psychiatry
Josef Frank - Department of Psychiatry and Behavioral Sciences
Barbara Franke - Department of Psychiatry and Behavioral Sciences
Christine Fraser - Institute of Psychological Medicine and Clinical Neurosciences
Publication Details: Nature genetics, Vol.45(9), pp.984-94
Publisher: Nature Publishing Group
Academic Unit: Miller School of Medicine; John P. Hussman Institute for Human Genomics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 23933821
PMCID: PMC3800159
Record Identifier: 991031560296702976