Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

Akira Komiya; John D Carpten; Angelo M DeMarzo; Aubrey Turner; G. Steven Bova; Ethan M Lange; Josyf C Mychaleckyj; Patrick C Walsh; William B Isaacs; David L McCullough; Jill Ohar; Jianfeng Xu; Joan E Bailey-Wilson; Deborah A Meyers; Piroska Bujnovszky; David Sterling; Eugene R Bleecker; Baoli Chang; Vahan S Kassabian; Gregory A Hawkins; Kathleen E Wiley; Charles M Ewing; Jennifer J Hu; Jill R Johnson; M. Craig Hall; Hiroyoshi Suzuki; Jeffrey M Trent; Sarah D Isaacs; Alan W Partin; Dennis A Faith; S. Lilly Zheng

doi:10.1038/ng994

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Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

Journal article

Peer reviewed

Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

Akira Komiya, John D Carpten, Angelo M DeMarzo, Aubrey Turner, G. Steven Bova, Ethan M Lange, Josyf C Mychaleckyj, Patrick C Walsh, William B Isaacs, David L McCullough, …

Nature genetics, Vol.32(2), pp.321-325

2002-10

DOI: https://doi.org/10.1038/ng994

PMID: 12244320

Abstract

Deletions on human chromosome 8p22-23 in prostate cancer cells and linkage studies in families affected with hereditary prostate cancer (HPC) have implicated this region in the development of prostate cancer. The macrophage scavenger receptor 1 gene (MSR1, also known as SR-A) is located at 8p22 and functions in several processes proposed to be relevant to prostate carcinogenesis. Here we report the results of genetic analyses that indicate that mutations in MSR1 may be associated with risk of prostate cancer. Among families affected with HPC, we identified six rare missense mutations and one nonsense mutation in MSR1. A family-based linkage and association test indicated that these mutations co-segregate with prostate cancer (P = 0.0007). In addition, among men of European descent, MSR1 mutations were detected in 4.4% of individuals affected with non-HPC as compared with 0.8% of unaffected men (P = 0.009). Among African American men, these values were 12.5% and 1.8%, respectively (P = 0.01). These results show that MSR1 may be important in susceptibility to prostate cancer in men of both African American and European descent.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.597 BRCA1
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics

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Title: Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
Creators: Akira Komiya - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
John D Carpten - National Human Genome Research Institute, National Institutes of Health
Angelo M DeMarzo - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
Aubrey Turner - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
G. Steven Bova - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
Ethan M Lange - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Josyf C Mychaleckyj - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Patrick C Walsh - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
William B Isaacs - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
David L McCullough - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Jill Ohar - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Jianfeng Xu - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Joan E Bailey-Wilson - National Human Genome Research Institute, National Institutes of Health
Deborah A Meyers - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Piroska Bujnovszky - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
David Sterling - Department of Medicine, St Louis University
Eugene R Bleecker - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Baoli Chang - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Vahan S Kassabian - Georgia Urology
Gregory A Hawkins - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Kathleen E Wiley - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
Charles M Ewing - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
Jennifer J Hu - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Jill R Johnson - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
M. Craig Hall - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Hiroyoshi Suzuki - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
Jeffrey M Trent - National Human Genome Research Institute, National Institutes of Health
Sarah D Isaacs - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
Alan W Partin - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
Dennis A Faith - Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions
S. Lilly Zheng - Center for Human Genomics and the Departments of Public Health, Medicine, Pediatrics, Urology and Cancer Biology, Wake Forest University School of Medicine
Publication Details: Nature genetics, Vol.32(2), pp.321-325
Academic Unit: Miller School of Medicine; UMMG Department of Public Health Sciences Research
Language: English
Resource Type: Journal article
PMID: 12244320
Record Identifier: 991031559548702976