Glycoprotein gene sequence variation in rhesus monkey rhadinovirus

Young C Shin; Leandro R Jones; Julieta Manrique; William Lauer; Angela Carville; Keith G Mansfield; Ronald C Desrosiers

doi:10.1016/j.virol.2010.01.030

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Glycoprotein gene sequence variation in rhesus monkey rhadinovirus

Journal article

Open access

Peer reviewed

Glycoprotein gene sequence variation in rhesus monkey rhadinovirus

Young C Shin, Leandro R Jones, Julieta Manrique, William Lauer, Angela Carville, Keith G Mansfield and Ronald C Desrosiers

Virology (New York, N.Y.), Vol.400(2), pp.175-186

2010

DOI: https://doi.org/10.1016/j.virol.2010.01.030

PMCID: PMC2852144

PMID: 20172576

Abstract

RRV glycoprotein

Variation

Phylogenetic grouping

Gene sequences for seven glycoproteins from 20 independent isolates of rhesus monkey rhadinovirus (RRV) and of the corresponding seven glycoprotein genes from nine strains of the Kaposi's sarcoma-associated herpesvirus (KSHV) were obtained and analyzed. Phylogenetic analysis revealed two discrete groupings of RRV gH sequences, two discrete groupings of RRV gL sequences and two discrete groupings of RRV gB sequences. We called these phylogenetic groupings gH a, gH b, gL a, gL b, gB a and gB b. gH a was always paired with gL a and gH b was always paired with gL b for any individual RRV isolate. Since gH and gL are known to be interacting partners, these results suggest the need of matching sequence types for function of these cooperating proteins. gB phylogenetic grouping was not associated with gH/gL phylogenetic grouping. Our results demonstrate two distinct, distantly-related phylogenetic groupings of gH and gL of RRV despite a remarkable degree of sequence conservation within each individual phylogenetic group.

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Collaboration types: International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.130 Lymphomas; 1.130.1220 Kaposi
Web Of Science research areas: Virology
ESI research areas: Microbiology

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Details

Title: Glycoprotein gene sequence variation in rhesus monkey rhadinovirus
Creators: Young C Shin - New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772-9102, USA
Leandro R Jones - Division of Molecular Biology, Estación de Fotobiología Playa Unión, Casilla de Correo 15, Rawson, Chubut, Argentina
Julieta Manrique - Division of Molecular Biology, Estación de Fotobiología Playa Unión, Casilla de Correo 15, Rawson, Chubut, Argentina
William Lauer - New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772-9102, USA
Angela Carville - New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772-9102, USA
Keith G Mansfield - New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772-9102, USA
Ronald C Desrosiers - New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772-9102, USA
Publication Details: Virology (New York, N.Y.), Vol.400(2), pp.175-186
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 20172576
PMCID: PMC2852144
Record Identifier: 991031600857102976