HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

Sarah E Benner; Xianming Zhu; Sarah Hussain; Sander Florman; Yolanda Eby; Reinaldo E Fernandez; Darin Ostrander; Meenakshi Rana; Shane Ottmann; Jonathan Hand; Jennifer C Price; Marcus R Pereira; David Wojciechowski; Jacques Simkins; Valentina Stosor; Sapna A Mehta; Saima Aslam; Maricar Malinis; Ghady Haidar; Allan Massie; Melissa L Smith; Jonah Odim; Megan Morsheimer; Thomas C Quinn; Gregory M Laird; Robert Siliciano; Ashwin Balagopal; Dorry L Segev; Christine M Durand; Andrew D Redd; Aaron A R Tobian; Jacques Simkins-Cohen

doi:10.1093/infdis/jiad241

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HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

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HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

Sarah E Benner, Xianming Zhu, Sarah Hussain, Sander Florman, Yolanda Eby, Reinaldo E Fernandez, Darin Ostrander, Meenakshi Rana, Shane Ottmann, Jonathan Hand, …

The Journal of infectious diseases, Vol.228(9), pp.1274-1279

2023-11-02

DOI: https://doi.org/10.1093/infdis/jiad241

PMID: 37379584

Appears in Miller School of Medicine - Latest Publications

Abstract

Anti-Retroviral Agents - therapeutic use

CD4-Positive T-Lymphocytes

HIV Infections - drug therapy

HIV Seropositivity - drug therapy

Humans

Liver Transplantation

Proviruses

Viral Load

Virus Latency

The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV. Clinical Trials Registration. NCT02602262 and NCT03734393.

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Title: HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV
Creators: Sarah E Benner - Johns Hopkins University
Xianming Zhu - Johns Hopkins University
Sarah Hussain - Johns Hopkins University
Sander Florman - Icahn School of Medicine at Mount Sinai
Yolanda Eby - Johns Hopkins University
Reinaldo E Fernandez - Johns Hopkins University
Darin Ostrander - Johns Hopkins University
Meenakshi Rana - Icahn School of Medicine at Mount Sinai
Shane Ottmann - Johns Hopkins Medicine
Jonathan Hand - Ochsner Health System
Jennifer C Price - University of California, San Francisco
Marcus R Pereira - Columbia University Irving Medical Center
David Wojciechowski - The University of Texas Southwestern Medical Center
Jacques Simkins - University of Miami
Valentina Stosor - Northwestern University
Sapna A Mehta - Department of Medicine, New York University Grossman School of Medicine, New York University Langone Health, New York, New York, USA
Saima Aslam - University of California, San Diego
Maricar Malinis - Yale University
Ghady Haidar - University of Pittsburgh
Allan Massie - New York University
Melissa L Smith - University of Louisville
Jonah Odim - National Institutes of Health
Megan Morsheimer - National Institute of Allergy and Infectious Diseases
Thomas C Quinn - National Institutes of Health
Gregory M Laird - Accelevir Diagnostics, Baltimore, Maryland, USA
Robert Siliciano - Johns Hopkins University
Ashwin Balagopal - Johns Hopkins University
Dorry L Segev - New York University
Christine M Durand - Johns Hopkins University
Andrew D Redd - National Institutes of Health
Aaron A R Tobian - Johns Hopkins University
Jacques Simkins-Cohen - Miller School of Medicine
Publication Details: The Journal of infectious diseases, Vol.228(9), pp.1274-1279
Grant note: U01 AI138897 / NIAID NIH HHS U24 AI143502 / NIAID NIH HHS R01 AI120938 / NIAID NIH HHS UL1 TR001863 / NCATS NIH HHS U01 AI134591 / NIAID NIH HHS R01 DK131926 / NIDDK NIH HHS
Academic Unit: Miller School of Medicine; UMMG Dept of Medicine - Infectious Diseases
Language: English
Resource Type: Journal article
PMID: 37379584
Record Identifier: 991032795819702976