HIV vaccine trial exploits a dual and central role for innate immunity

Deborah Heydenburg Fuller; Laura E Richert-Spuhler; Nichole R Klatt

doi:10.1128/JVI.02140-14

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HIV vaccine trial exploits a dual and central role for innate immunity

Journal article

Open access

Peer reviewed

HIV vaccine trial exploits a dual and central role for innate immunity

Deborah Heydenburg Fuller, Laura E Richert-Spuhler and Nichole R Klatt

Journal of virology, Vol.88(20), pp.11640-11643

2014-10

DOI: https://doi.org/10.1128/JVI.02140-14

PMCID: PMC4178753

PMID: 25122775

Abstract

AIDS Vaccines - administration & dosage

Animals

Female

HIV Envelope Protein gp41 - immunology

HIV-1 - physiology

HSP70 Heat-Shock Proteins - immunology

Humans

Immunity, Innate

T-Lymphocytes - immunology

Vagina

Virus Replication - immunology

Limited understanding of correlates of protection from HIV transmission hinders development of an efficacious vaccine. D. J. M. Lewis and colleagues (J. Virol. 88:11648-11657, 2014, doi:10.1128/JVI.01621-14) now report that vaginal immunization with an HIVgp140 vaccine linked to the 70-kDa heat shock protein downregulated the human immunodeficiency virus (HIV) coreceptor CCR5 (chemokine [C-C motif] receptor 5) and increased expression of the HIV resistance factor APOBEC3G (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G), in women. These effects correlated with HIV suppression ex vivo. Thus, vaccine-induced innate responses not only facilitate adaptive immunity-they may prove to be critical for preventing HIV transmission.

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Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV-1
Web Of Science research areas: Virology
ESI research areas: Microbiology

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Title: HIV vaccine trial exploits a dual and central role for innate immunity
Creators: Deborah Heydenburg Fuller - Department of Microbiology, University of Washington, Seattle, Washington, USA Washington National Primate Research Center, Seattle, Washington, USA fullerdh@u.washington.edu klattnr@u.washington.edu
Laura E Richert-Spuhler - Washington National Primate Research Center, Seattle, Washington, USA Department of Pharmaceutics, University of Washington, Seattle, Washington, USA
Nichole R Klatt - Washington National Primate Research Center, Seattle, Washington, USA Department of Pharmaceutics, University of Washington, Seattle, Washington, USA fullerdh@u.washington.edu klattnr@u.washington.edu
Publication Details: Journal of virology, Vol.88(20), pp.11640-11643
Grant note: P51 OD010425 / NIH HHS T32 AI007140 / NIAID NIH HHS
Academic Unit: UMMG Department of Pediatrics
Language: English
Resource Type: Journal article
PMID: 25122775
PMCID: PMC4178753
Record Identifier: 991031614042102976