Abstract
The unprecedented generation of biological data and the computational intensity of modern biomedical research demand transformative solutions. High-Performance Computing (HPC) and Artificial Intelligence (AI) have emerged as pivotal technologies driving innovation in bioinformatics. The combination of AI and HPC has revolutionized genomics, drug discovery, and precision medicine. This special issue invited review and research articles on the latest trends in HPC and AI technologies for biomedical and biological research. Overall 8 papers were accepted in this issue covering a wide range of research areas, including virtual drug screening, biological sequence analysis, drug-target interaction/drug-disease association, metagenomics etc.