Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy–Treated Human Immunodeficiency Virus–Infected Individuals

Jennifer A Manuzak; Toni M Gott; Jay S Kirkwood; Ernesto Coronado; Tiffany Hensley-McBain; Charlene Miller; Ryan K Cheu; Ann C Collier; Nicholas T Funderburg; Jeffery N Martin; Michael C Wu; Nina Isoherranen; Peter W Hunt; Nichole R Klatt

doi:10.1093/cid/cix1116

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Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy–Treated Human Immunodeficiency Virus–Infected Individuals

Journal article

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Peer reviewed

Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy–Treated Human Immunodeficiency Virus–Infected Individuals

Jennifer A Manuzak, Toni M Gott, Jay S Kirkwood, Ernesto Coronado, Tiffany Hensley-McBain, Charlene Miller, Ryan K Cheu, Ann C Collier, Nicholas T Funderburg, Jeffery N Martin, …

Clinical infectious diseases, Vol.66(12), pp.1872-1882

2018-06-15

DOI: https://doi.org/10.1093/cid/cix1116

PMCID: PMC6248381

PMID: 29471387

Abstract

adaptive immunity

and Commentaries

cannabis

Editor's Choice

HIV

immune activation

innate immunity

We assessed whether cannabis use was associated with altered immune activation in antiretroviral-treated, HIV-infected individuals. Heavy cannabis use was associated with decreased frequencies of activated T cells and inflammatory monocytes, providing evidence of a potential immunological benefit of cannabinoids.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.100 Substance Abuse; 1.100.625 Cannabinoids
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology
ESI research areas: Immunology

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Title: Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy–Treated Human Immunodeficiency Virus–Infected Individuals
Creators: Jennifer A Manuzak - Department of Pharmaceutics, University of Washington
Toni M Gott - Department of Pharmaceutics, University of Washington
Jay S Kirkwood - Department of Pharmaceutics, University of Washington
Ernesto Coronado - Department of Pharmaceutics, University of Washington
Tiffany Hensley-McBain - Department of Pharmaceutics, University of Washington
Charlene Miller - Department of Pharmaceutics, University of Washington
Ryan K Cheu - Department of Pharmaceutics, University of Washington
Ann C Collier - Department of Medicine, Harborview Medical Center, University of Washington, Seattle
Nicholas T Funderburg - School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Ohio State University, Columbus
Jeffery N Martin - Department of Epidemiology and Biostatistics, University of California, San Francisco
Michael C Wu - Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
Nina Isoherranen - Department of Pharmaceutics, University of Washington
Peter W Hunt - Department of Medicine, University of California, San Francisco
Nichole R Klatt - Department of Pharmaceutics, University of Washington
Publication Details: Clinical infectious diseases, Vol.66(12), pp.1872-1882
Publisher: Oxford University Press
Academic Unit: Miller School of Medicine; UMMG Department of Pediatrics; UMMG Dept of Pediatrics - Infectious Diseases
Language: English
Resource Type: Journal article
PMID: 29471387
PMCID: PMC6248381
Record Identifier: 991031614512402976