Higher MICs (>2 mg/L) Predict 30-Day Mortality in Patients With Lower Respiratory Tract Infections Caused by Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa Treated With Ceftolozane/Tazobactam

Olga Rodríguez-Núñez; Leonor Periañez-Parraga; Antonio Oliver; Jose M Munita; Anna Boté; Oriol Gasch; Xavier Nuvials; Aurélien Dinh; Robert Shaw; Jose M Lomas; Vicente Torres; Juanjo Castón; Rafael Araos; Lilian M Abbo; Robert Rakita; Federico Pérez; Samuel L Aitken; Cesar A Arias; M Luisa Martín-Pena; Asun Colomar; M Belén Núñez; Josep Mensa; José Antonio Martínez; Alex Soriano

doi:10.1093/ofid/ofz416

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Higher MICs (>2 mg/L) Predict 30-Day Mortality in Patients With Lower Respiratory Tract Infections Caused by Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa Treated With Ceftolozane/Tazobactam

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Higher MICs (>2 mg/L) Predict 30-Day Mortality in Patients With Lower Respiratory Tract Infections Caused by Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa Treated With Ceftolozane/Tazobactam

Olga Rodríguez-Núñez, Leonor Periañez-Parraga, Antonio Oliver, Jose M Munita, Anna Boté, Oriol Gasch, Xavier Nuvials, Aurélien Dinh, Robert Shaw, Jose M Lomas, …

Open forum infectious diseases, Vol.6(10), pp.ofz416-ofz416

2019-10-01

DOI: https://doi.org/10.1093/ofid/ofz416

PMCID: PMC6810667

PMID: 31660373

Abstract

Major

pneumonia

tazobactam

Pseudomonas aeruginosa

tracheobronchitis

ceftolozane

multidrug-resistant

This study evaluates the efficacy of different doses of ceftolozane/tazobactam in patients with respiratory infections due to resistant P. aeruginosa . Ceftolozane/tazobactam (C/T) effectiveness was associated with a minimal inhibitory concentration (MIC) ≤2 mg/L. The lowest mortality was observed when high doses were administered for C/T MIC ≤2 mg/L strains.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.146 Antibiotic Resistance
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology
ESI research areas: Immunology

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Title: Higher MICs (>2 mg/L) Predict 30-Day Mortality in Patients With Lower Respiratory Tract Infections Caused by Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa Treated With Ceftolozane/Tazobactam
Creators: Olga Rodríguez-Núñez - Servicio de Enfermedades Infecciosas, Hospital Clínic
Leonor Periañez-Parraga - Servicio de Farmacia Hospitalaria, Hospital Universitari Son Espases
Antonio Oliver - Servicio de Microbiología, Hospital Universitari Son Espases
Jose M Munita - Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School
Anna Boté - Servicio de Enfermedades Infecciosas, Hospital Universitari Parc Taulí
Oriol Gasch - Servicio de Enfermedades Infecciosas, Hospital Universitari Parc Taulí
Xavier Nuvials - Unidad de Cuidados Intensivos, Hospital Vall d’Hebron
Aurélien Dinh - Department of Infectious Diseases
Robert Shaw - Department of Infectious Diseases
Jose M Lomas - Department of Infectious Diseases
Vicente Torres - Unidad de Cuidados Intensivos, Hospital Son Espases
Juanjo Castón - Unidad Clínica de Enfermedades Infecciosas, Hospital Universitario Reina Sofía-IMIBIC
Rafael Araos - Genomics & Resistant Microbes (GeRM), Instituto de Ciencias e Innovación en Medicina, Clínica Alemana, Universidad del Desarrollo and Millenium Initiative for Collaborative Research Bacterial Resistance (MICROB-R)
Lilian M Abbo - Department of Medicine, Jackson Memorial Hospital and Division of Infectious Diseases, University of Miami Miller School of Medicine
Robert Rakita - Division of Allergy and Infectious Diseases, University of Washington
Federico Pérez - Cleveland Veterans Affairs Medical Center, Case Western Reserve University
Samuel L Aitken - Division of Pharmacy
Cesar A Arias - Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School
M Luisa Martín-Pena - Servicio de Medicina Interna, Hospital Universitari Son Espases
Asun Colomar - Unidad de Cuidados Intensivos, Hospital Universitari Son Espases
M Belén Núñez - Servicio de Neumología, Hospital Universitari Son Espases
Josep Mensa - Servicio de Enfermedades Infecciosas, Hospital Clínic
José Antonio Martínez - Servicio de Enfermedades Infecciosas, Hospital Clínic
Alex Soriano - Servicio de Enfermedades Infecciosas, Hospital Clínic
Publication Details: Open forum infectious diseases, Vol.6(10), pp.ofz416-ofz416
Publisher: Oxford University Press; US
Academic Unit: UMMG Dept of Medicine - Infectious Diseases; Miller School of Medicine
Language: English
Resource Type: Journal article
PMID: 31660373
PMCID: PMC6810667
Record Identifier: 991031577858802976