Highly efficient one-pot multienzyme (OPME) synthesis of glycans with fluorous-tag assisted purification

Joel Hwang; Hai Yu; Hamed Malekan; Go Sugiarto; Yanhong Li; Jingyao Qu; Van Nguyen; Dongyuan Wu; Xi Chen

doi:10.1039/C4CC00070F

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Journal article

Highly efficient one-pot multienzyme (OPME) synthesis of glycans with fluorous-tag assisted purification

Joel Hwang, Hai Yu, Hamed Malekan, Go Sugiarto, Yanhong Li, Jingyao Qu, Van Nguyen, Dongyuan Wu and Xi Chen

Chemical communications (Cambridge, England), Vol.50(24), pp.3159-3162

2014

DOI: https://doi.org/10.1039/C4CC00070F

PMID: 24473465

Abstract

Oligo(ethylene glycol)-linked light fluorous tags have been found to be optimal for conjugating to glycans for both high-yield enzymatic glycosylation reactions using one-pot multienzyme (OPME) systems and quick product purification using fluorous solid-phase extraction (FSPE) cartridges. The combination of OPME glycosylation systems and the FSPE cartridge purification scheme provides a highly effective strategy for facile synthesis and purification of glycans.

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Citation topics: 2 Chemistry; 2.1 Synthesis; 2.1.522 Thioglycosides
Web Of Science research areas: Chemistry, Multidisciplinary
ESI research areas: Chemistry

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Details

Title: Highly efficient one-pot multienzyme (OPME) synthesis of glycans with fluorous-tag assisted purification
Creators: Joel Hwang - Department of Chemistry, University of California, Davis, USA
Hai Yu - Department of Chemistry, University of California, Davis, USA
Hamed Malekan - Department of Chemistry, University of California, Davis, USA
Go Sugiarto - Department of Chemistry, University of California, Davis, USA
Yanhong Li - Department of Chemistry, University of California, Davis, USA
Jingyao Qu - Department of Chemistry, University of California, Davis, USA
Van Nguyen - Department of Chemistry, University of California, Davis, USA
Dongyuan Wu - Department of Chemistry, University of California, Davis, USA
Xi Chen - Department of Chemistry, University of California, Davis, USA
Publication Details: Chemical communications (Cambridge, England), Vol.50(24), pp.3159-3162
Academic Unit: Miller School of Medicine; UMMG Department of Public Health Sciences Research
Language: English
Resource Type: Journal article
PMID: 24473465
Record Identifier: 991031599723602976