Human embryonic stem cell derivation from poor-quality embryos

Akiko Yabuuchi; Jessica Shea; Hongguang Huo; Ayumu Takeuchi; Paul H Lerou; Elizabeth Ginsburg; Tan A Ince; Catherine Racowsky; George Q Daley; Tina Cimini

doi:10.1038/nbt1378

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Human embryonic stem cell derivation from poor-quality embryos

Journal article

Peer reviewed

Human embryonic stem cell derivation from poor-quality embryos

Akiko Yabuuchi, Jessica Shea, Hongguang Huo, Ayumu Takeuchi, Paul H Lerou, Elizabeth Ginsburg, Tan A Ince, Catherine Racowsky, George Q Daley and Tina Cimini

Nature biotechnology, Vol.26(2), pp.212-214

2008-02

DOI: https://doi.org/10.1038/nbt1378

PMID: 18223642

Abstract

During in vitro fertilization, embryos deemed clinically useless based on poor morphology are typically discarded. Here we demonstrate a statistical correlation between the developmental stage of such poor-quality embryos and the yield of human embryonic stem (hES) cell lines. Early-arrested or highly fragmented embryos only rarely yield cell lines, whereas those that have achieved blastocyst stage are a robust source of normal hES cells.

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Citation topics: 1 Clinical & Life Sciences; 1.102 Stem Cell Research; 1.102.622 Pluripotency
Web Of Science research areas: Biotechnology & Applied Microbiology
ESI research areas: Biology & Biochemistry

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Details

Title: Human embryonic stem cell derivation from poor-quality embryos
Creators: Akiko Yabuuchi - Division of Pediatric Hematology Oncology, Children's Hospital Boston Harvard Stem Cell Institute, Karp Family Research Building 7214
Jessica Shea - Biological and Biomedical Sciences, Harvard Medical School
Hongguang Huo - Division of Pediatric Hematology Oncology, Children's Hospital Boston Harvard Stem Cell Institute, Karp Family Research Building 7214
Ayumu Takeuchi - Division of Pediatric Hematology Oncology, Children's Hospital Boston Harvard Stem Cell Institute, Karp Family Research Building 7214
Paul H Lerou - Division of Newborn Medicine, Brigham & Women's Hospital and Children's Hospital Boston, Karp Family Research Building 7214 Harvard Stem Cell Institute, Karp Family Research Building 7214
Elizabeth Ginsburg - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham & Women’s Hospital, Harvard Medical School
Tan A Ince - Division of Women's and Perinatal Pathology, Department of Pathology, Brigham & Women's Hospital, Harvard Medical School
Catherine Racowsky - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham & Women’s Hospital, Harvard Medical School
George Q Daley - Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Karp Family Research Building 7214
Tina Cimini - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham & Women’s Hospital, Harvard Medical School
Publication Details: Nature biotechnology, Vol.26(2), pp.212-214
Language: English
Resource Type: Journal article
PMID: 18223642
Record Identifier: 991031613679102976