Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The GenePD Study

Christopher F McNicoll; Jeanne C Latourelle; Marcy E MacDonald; Mark F Lew; Oksana Suchowersky; Christine Klein; Lawrence I Golbe; Margery H Mark; John H Growdon; G. Frederick Wooten; Ray L Watts; Mark Guttman; Brad A Racette; Joel S Perlmutter; Anwar Ahmed; Holly A Shill; Carlos Singer; Marie H Saint-Hilaire; Tiffany Massood; Karen W Huskey; Anita L DeStefano; Tammy Gillis; Jayalakshmi Mysore; Stefano Goldwurm; Gianni Pezzoli; Kenneth B Baker; Ilia Itin; Irene Litvan; Garth Nicholson; Alastair Corbett; Martha Nance; Edward Drasby; Stuart Isaacson; David J Burn; Patrick F Chinnery; Peter P Pramstaller; Jomana Al-hinti; Anette T Moller; Karen Ostergaard; Scott J Sherman; Richard Roxburgh; Barry Snow; John T Slevin; Franca Cambi; James F Gusella; Richard H Myers

doi:10.1002/mds.22186

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Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The GenePD Study

Journal article

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Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The GenePD Study

Christopher F McNicoll, Jeanne C Latourelle, Marcy E MacDonald, Mark F Lew, Oksana Suchowersky, Christine Klein, Lawrence I Golbe, Margery H Mark, John H Growdon, G. Frederick Wooten, …

Movement disorders, Vol.23(11), pp.1596-1601

2008-08-15

DOI: https://doi.org/10.1002/mds.22186

PMCID: PMC2655323

PMID: 18649400

Abstract

Huntington’s disease

genetics

onset age

CAG repeat

mitochondria

Parkinson’s disease

The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene ( HD ) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson’s disease (PD) and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n=495) with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range 15 to 34) below the clinical range for HD, although 5.2 percent of the sample (n=25) had repeats in the intermediate range (the intermediate range lower limit=27; upper limit=35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.951 Huntington's Disease
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior

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Title: Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The GenePD Study
Creators: Christopher F McNicoll - Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA
Jeanne C Latourelle - Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA
Marcy E MacDonald - Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA
Mark F Lew - Department of Neurology, University of Southern California, Los Angeles, CA
Oksana Suchowersky - Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta, Canada
Christine Klein - Department of Neurology, Medical University of Lübeck, Lübeck, Germany
Lawrence I Golbe - Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ
Margery H Mark - Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ
John H Growdon - Department of Neurology, Massachusetts General Hospital, Harvard Medical School Boston, MA
G. Frederick Wooten - Department of Neurology, University of Virginia Health System, Charlottesville, VA
Ray L Watts - Department of Neurology, University of Alabama at Birmingham, Birmingham AL
Mark Guttman - Department of Medicine, University of Toronto, Toronto, Canada
Brad A Racette - Department of Neurology, Washington University School of Medicine, Saint Louis, MO
Joel S Perlmutter - Department of Neurology, Washington University School of Medicine, Saint Louis, MO
Anwar Ahmed - Barrow Neurological Institute, Phoenix AZ
Holly A Shill - Sun Health Research Institute, Sun City AZ
Carlos Singer - Department of Neurology, University of Miami, Miami, FL
Marie H Saint-Hilaire - Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA
Tiffany Massood - Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA
Karen W Huskey - Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA
Anita L DeStefano - Department of Biostatistics, Boston University School of Medicine, Boston University, Boston, MA
Tammy Gillis - Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA
Jayalakshmi Mysore - Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA
Stefano Goldwurm - Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy
Gianni Pezzoli - Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy
Kenneth B Baker - Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH
Ilia Itin - Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH
Irene Litvan - Department of Neurology, University of Louisville School of Medicine, Louisville, KY
Garth Nicholson - Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia
Alastair Corbett - Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia
Martha Nance - Struthers Parkinson’s Center, Park Nicollet Clinic, Golden Valley, MN
Edward Drasby - Port City Neurology, Scarborough, ME
Stuart Isaacson - Parkinson’s Disease and Movement Disorder Center of Boca Raton, Boca Raton, FL
David J Burn - Institute for Ageing and Health, Newcastle upon Tyne, UK
Patrick F Chinnery - Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne, UK
Peter P Pramstaller - Department of Neurology, General Regional Hospital Bolzano, Bolzano, Italy
Jomana Al-hinti - Department of Neurology, University of Arkansas for Medical Sciences, AR
Anette T Moller - Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
Karen Ostergaard - Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
Scott J Sherman - Department of Neurology, University of Arizona, Tucson, AZ
Richard Roxburgh - Department of Neurology, Auckland City Hospital, Auckland, New Zealand
Barry Snow - Department of Neurology, Auckland City Hospital, Auckland, New Zealand
John T Slevin - Department of Neurology, University of Kentucky College of Medicine, Lexington, KY
Franca Cambi - Department of Neurology, University of Kentucky College of Medicine, Lexington, KY
James F Gusella - Molecular Neurogenetics Unit, Center for Human Genetic Research, Harvard Medical School Boston, MA
Richard H Myers - Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA
Publication Details: Movement disorders, Vol.23(11), pp.1596-1601
Academic Unit: Miller School of Medicine; UMMG Department of Neurology
Language: English
Resource Type: Journal article
PMID: 18649400
PMCID: PMC2655323
Record Identifier: 991031561913002976