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Hypercortisolemia and depression
Journal article   Peer reviewed

Hypercortisolemia and depression

Charles F Gillespie and Charles B Nemeroff
Psychosomatic medicine, Vol.67 Suppl 1(1), pp.S26-S28
2005-05
DOI: https://doi.org/10.1097/01.psy.0000163456.22154.d2
PMID: 15953796

Abstract

Depression - physiopathology Pituitary-Adrenal System - physiopathology Cushing Syndrome - physiopathology Dexamethasone Glucocorticoids Humans Adrenocorticotropic Hormone - biosynthesis Corticotropin-Releasing Hormone - biosynthesis Depressive Disorder - physiopathology Cushing Syndrome - blood Hypothalamo-Hypophyseal System - physiology Hypothalamo-Hypophyseal System - physiopathology Pituitary-Adrenal System - physiology
Hypercortisolemia and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis are often found in severe forms of depression. The authors review the history of techniques used to assess the functions of the HPA axis, evidence for hypercortisolemia as a state rather than trait component of depression, and treatment implications.

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Citation topics
1 Clinical & Life Sciences
1.5 Neuroscience
1.5.420 Cortisol
Web Of Science research areas
Psychiatry
Psychology
Psychology, Multidisciplinary
ESI research areas
Psychiatry/Psychology

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