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IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response
Journal article   Open access  Peer reviewed

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Felipe J Núñez, Flor M Mendez, Padma Kadiyala, Mahmoud S Alghamri, Masha G Savelieff, Maria B Garcia-Fabiani, Santiago Haase, Carl Koschmann, Anda-Alexandra Calinescu, Neha Kamran, …
Science translational medicine, Vol.11(479), p.eaaq1427
2019-02-13
PMID: 30760578

Abstract

Ataxia Telangiectasia Mutated Proteins - metabolism Epigenesis, Genetic Humans Radiation Tolerance Brain Neoplasms - pathology DNA Repair - genetics Glioma - genetics Glioma - pathology Tumor Suppressor Proteins - genetics DNA Damage - genetics Cell Differentiation Gene Ontology Disease Models, Animal Signal Transduction Brain Neoplasms - genetics Isocitrate Dehydrogenase - genetics Up-Regulation - genetics DNA Methylation - genetics Mutation - genetics Oligodendroglia - pathology Animals Survival Analysis Mice Histones - metabolism Genome
url
https://doi.org/10.1126/scitranslmed.aaq1427View
Published (Version of record) Open

InCites Highlights

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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.113 Brain Imaging
1.113.453 Glioblastoma
Web Of Science research areas
Cell Biology
Medicine, Research & Experimental
ESI research areas
Biology & Biochemistry

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#3 Good Health and Well-Being

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