Abstract
A major 56 kDa substrate for phospholipid/Ca2+‐dependent kinase (C‐kinase) in pancreatic acinar cells is physicochemically and immunologically indistinguishable from the vitamin D‐binding protein, Gc or group‐specific component. Cellular Gc was also phosphorylated in intact cells following treatment with carbachol as a physiological stimulus. These findings indicate the potential usefulness of Gc as a defined substrate for further studies of the biological role of C‐kinase activity in pancreatic acini and possibly in other cells.
