Abstract
A computationally designed mimic of interleukin-2 (IL-2) selectively expands cytotoxic CD8
T cells over regulatory T cells and supports antitumor immunity.
- Title
- If you build it, they will come: Reaching across the "IL" with Neo-2/15
- Creators
- Kelly Andrews - Department of Pediatrics, Division of Hematology/Oncology and Bone Marrow Transplantation, Batchelor Children's Research Institute, Department of Microbiology & Immunology, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. Email: kelly.andrews@med.miami.eduAsha Pillai - Department of Pediatrics, Division of Hematology/Oncology and Bone Marrow Transplantation, Batchelor Children's Research Institute, Department of Microbiology & Immunology, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. Email: kelly.andrews@med.miami.edu
- Publication Details
- Science immunology, Vol.4(33), p.eaax1017
- Publisher
- United States
- Grant note
- R01 HL133462 / NHLBI NIH HHS
- Academic Unit
- Miller School of Medicine; UMMG Department of Pediatrics; UMMG Dept of Pediatrics - Hematology/Oncology/Stem Cell Transp
- Language
- English
- Resource Type
- Journal article
- PMID
- 30824529
- Record Identifier
- 991031577002802976