Impact of Synchronous Metastasis Distribution on Cancer Specific Survival in Renal Cell Carcinoma after Radical Nephrectomy with Tumor Thrombectomy

Derya Tilki; Brian Hu; Hao G Nguyen; Marc A Dall’Era; Roberto Bertini; Joaquín A Carballido; Thenappan Chandrasekar; Thomas Chromecki; Gaetano Ciancio; Siamak Daneshmand; Paolo Gontero; Javier Gonzalez; Axel Haferkamp; Markus Hohenfellner; William C Huang; Theresa M Koppie; Estefania Linares; C. Adam Lorentz; Philipp Mandel; Juan I Martinez-Salamanca; Viraj A Master; Rayan Matloob; James M McKiernan; Carrie M Mlynarczyk; Francesco Montorsi; Giacomo Novara; Sascha Pahernik; Juan Palou; Raj S Pruthi; Krishna Ramaswamy; Oscar Rodriguez Faba; Paul Russo; Shahrokh F Shariat; Martin Spahn; Carlo Terrone; William Thieu; Daniel Vergho; Eric M Wallen; Evanguelos Xylinas; Richard Zigeuner; John A Libertino; Christopher P Evans

doi:10.1016/j.juro.2014.07.087

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Impact of Synchronous Metastasis Distribution on Cancer Specific Survival in Renal Cell Carcinoma after Radical Nephrectomy with Tumor Thrombectomy

Journal article

Peer reviewed

Impact of Synchronous Metastasis Distribution on Cancer Specific Survival in Renal Cell Carcinoma after Radical Nephrectomy with Tumor Thrombectomy

Derya Tilki, Brian Hu, Hao G Nguyen, Marc A Dall’Era, Roberto Bertini, Joaquín A Carballido, Thenappan Chandrasekar, Thomas Chromecki, Gaetano Ciancio, Siamak Daneshmand, …

The Journal of urology, Vol.193(2), pp.436-442

2015-02

DOI: https://doi.org/10.1016/j.juro.2014.07.087

PMID: 25063493

Abstract

vena cava

renal cell

carcinoma

inferior

survival

neoplasm metastasis

prognosis

Metastatic renal cell carcinoma can be clinically diverse in terms of the pattern of metastatic disease and response to treatment. We studied the impact of metastasis and location on cancer specific survival. The records of 2,017 patients with renal cell cancer and tumor thrombus who underwent radical nephrectomy and tumor thrombectomy from 1971 to 2012 at 22 centers in the United States and Europe were analyzed. Number and location of synchronous metastases were compared with respect to patient cancer specific survival. Multivariable Cox regression models were used to quantify the impact of covariates. Lymph node metastasis (155) or distant metastasis (725) was present in 880 (44%) patients. Of the patients with distant disease 385 (53%) had an isolated metastasis. The 5-year cancer specific survival was 51.3% (95% CI 48.6–53.9) for the entire group. On univariable analysis patients with isolated lymph node metastasis had a significantly worse cancer specific survival than those with a solitary distant metastasis. The location of distant metastasis did not have any significant effect on cancer specific survival. On multivariable analysis the presence of lymph node metastasis, isolated distant metastasis and multiple distant metastases were independently associated with cancer specific survival. Moreover higher tumor thrombus level, papillary histology and the use of postoperative systemic therapy were independently associated with worse cancer specific survival. In our multi-institutional series of patients with renal cell cancer who underwent radical nephrectomy and tumor thrombectomy, almost half of the patients had synchronous lymph node or distant organ metastasis. Survival was superior in patients with solitary distant metastasis compared to isolated lymph node disease.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.233 Pelvic & Renal Disorders; 1.233.501 Renal Cell Carcinoma
Web Of Science research areas: Urology & Nephrology
ESI research areas: Clinical Medicine

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Title: Impact of Synchronous Metastasis Distribution on Cancer Specific Survival in Renal Cell Carcinoma after Radical Nephrectomy with Tumor Thrombectomy
Creators: Derya Tilki - Department of Urology, University of California, Davis School of Medicine, Sacramento, California
Brian Hu - Department of Urology, University of California, Davis School of Medicine, Sacramento, California
Hao G Nguyen - Department of Urology, University of California, Davis School of Medicine, Sacramento, California
Marc A Dall’Era - Department of Urology, University of California, Davis School of Medicine, Sacramento, California
Roberto Bertini - Department of Urology, Hospital San Raffaele, University Vita-Salute, Milano, Italy
Joaquín A Carballido - Department of Urology, Hospital Universitario Puerta de Hierro-Majadahonda, Universidad Autónoma de Madrid, Madrid, Spain
Thenappan Chandrasekar - Department of Urology, University of California, Davis School of Medicine, Sacramento, California
Thomas Chromecki - Department of Urology, Medical University of Graz, Graz, Austria
Gaetano Ciancio - Miami Transplant Institute, University of Miami, Miami, Florida
Siamak Daneshmand - USC/Norris Comprehensive Cancer Center, Los Angeles, California
Paolo Gontero - Department of Urology, A.O.U. San Giovanni Battista, University of Turin, Turin, Italy
Javier Gonzalez - Department of Urology, Hospital Central de la Cruz Roja San José y Santa Adela, Madrid, Spain
Axel Haferkamp - Department of Urology, University of Frankfurt, Frankfurt, Germany
Markus Hohenfellner - Department of Urology, University of Heidelberg, Heidelberg, Germany
William C Huang - Department of Urology, New York University School of Medicine, New York, New York
Theresa M Koppie - Department of Urology, Oregon Health & Science University, Portland, Oregon
Estefania Linares - Department of Urology, Hospital Universitario Puerta de Hierro-Majadahonda, Universidad Autónoma de Madrid, Madrid, Spain
C. Adam Lorentz - Department of Urology, Emory University, Atlanta, Georgia
Philipp Mandel - Institute of Empirical Economic Research, University of Leipzig, Leipzig, Germany
Juan I Martinez-Salamanca - Department of Urology, Hospital Universitario Puerta de Hierro-Majadahonda, Universidad Autónoma de Madrid, Madrid, Spain
Viraj A Master - Department of Urology, Emory University, Atlanta, Georgia
Rayan Matloob - Department of Urology, Hospital San Raffaele, University Vita-Salute, Milano, Italy
James M McKiernan - Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York
Carrie M Mlynarczyk - Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York
Francesco Montorsi - Department of Urology, Hospital San Raffaele, University Vita-Salute, Milano, Italy
Giacomo Novara - University of Padua, Padua, Italy
Sascha Pahernik - Department of Urology, University of Heidelberg, Heidelberg, Germany
Juan Palou - Department of Urology, Fundació Puigvert, Barcelona, Spain
Raj S Pruthi - Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Krishna Ramaswamy - Department of Urology, New York University School of Medicine, New York, New York
Oscar Rodriguez Faba - Department of Urology, Fundació Puigvert, Barcelona, Spain
Paul Russo - Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York
Shahrokh F Shariat - Department of Urology, Medical University of Vienna, Vienna General Hospital, Vienna, Austria
Martin Spahn - University of Würzburg, Würzburg, Germany
Carlo Terrone - Division of Urology, Maggiore della Carita Hospital, University of Eastern Piedmont, Novara, Italy
William Thieu - Department of Urology, University of California, Davis School of Medicine, Sacramento, California
Daniel Vergho - University of Würzburg, Würzburg, Germany
Eric M Wallen - Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Evanguelos Xylinas - Department of Urology, Weill Cornell Medical Center, New York, New York
Richard Zigeuner - Department of Urology, Medical University of Graz, Graz, Austria
John A Libertino - Department of Urology, Lahey Clinic, Burlington, Massachusetts
Christopher P Evans - Department of Urology, University of California, Davis School of Medicine, Sacramento, California
Publication Details: The Journal of urology, Vol.193(2), pp.436-442
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Department of Surgery; UMMG Dept of Surgery - Div of Kidney & Pancreas Transplantation
Language: English
Resource Type: Journal article
PMID: 25063493
Record Identifier: 991031578784902976