Implementation of preemptive DNA sequence–based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

Liewei Wang; Steven E. Scherer; Suzette J. Bielinski; Donna M. Muzny; Leila A. Jones; John Logan Black; Ann M. Moyer; Jyothsna Giri; Richard R. Sharp; Eric T. Matey; Jessica A. Wright; Lance J. Oyen; Wayne T. Nicholson; Mathieu Wiepert; Terri Sullard; Timothy B. Curry; Carolyn R. Rohrer Vitek; Tammy M. McAllister; Jennifer L. St. Sauver; Pedro J. Caraballo; Konstantinos N. Lazaridis; Eric Venner; Xiang Qin; Jianhong Hu; Christie L. Kovar; Viktoriya Korchina; Kimberly Walker; HarshaVardhan Doddapaneni; Tsung-Jung Wu; Ritika Raj; Shawn Denson; Wen Liu; Gauthami Chandanavelli; Lan Zhang; Qiaoyan Wang; Divya Kalra; Mary Beth Karow; Kimberley J. Harris; Hugues Sicotte; Sandra E. Peterson; Amy E. Barthel; Brenda E. Moore; Jennifer M. Skierka; Michelle L. Kluge; Katrina E. Kotzer; Karen Kloke; Jessica M. Vander Pol; Heather Marker; Joseph A. Sutton; Adrijana Kekic; Ashley Ebenhoh; Dennis M. Bierle; Michael J. Schuh; Christopher Grilli; Sara Erickson; Audrey Umbreit; Leah Ward; Sheena Crosby; Eric A. Nelson; Sharon Levey; Michelle Elliott; Steve G. Peters; Naveen Pereira; Mark Frye; Fadi Shamoun; Matthew P. Goetz; Iftikhar J. Kullo; Robert Wermers; Jan A. Anderson; Christine M. Formea; Razan M. El Melik; John D. Zeuli; Joseph R. Herges; Carrie A. Krieger; Robert W. Hoel; Jodi L. Taraba; Scott R. St. Thomas; Imad Absah; Matthew E. Bernard; Stephanie R. Fink; Andrea Gossard; Pamela L. Grubbs; Therese M. Jacobson; Paul Takahashi; Sharon C. Zehe; Susan Buckles; Michelle Bumgardner; Colette Gallagher; Kelliann Fee-Schroeder; Nichole R. Nicholas; Melody L. Powers; Ahmed K. Ragab; Darcy M. Richardson; Anthony Stai; Jaymi Wilson; Joel E. Pacyna; Janet E. Olson; Erica J. Sutton; Annika T. Beck; Caroline Horrow; Krishna R. Kalari; Nicholas B. Larson; Hongfang Liu; Liwei Wang; Guilherme S. Lopes; Bijan J. Borah; Robert R. Freimuth; Ye Zhu; Debra J. Jacobson; Matthew A. Hathcock; Sebastian M. Armasu; Michaela E. McGree; Ruoxiang Jiang; Tyler H. Koep; Jason L. Ross; Matthew G. Hilden; Kathleen Bosse; Bronwyn Ramey; Isabelle Searcy; Eric Boerwinkle; Richard A. Gibbs; Richard M. Weinshilboum

doi:10.1016/j.gim.2022.01.022

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Implementation of preemptive DNA sequence–based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

Journal article

Peer reviewed

Implementation of preemptive DNA sequence–based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

Liewei Wang, Steven E. Scherer, Suzette J. Bielinski, Donna M. Muzny, Leila A. Jones, John Logan Black, Ann M. Moyer, Jyothsna Giri, Richard R. Sharp, Eric T. Matey, …

Genetics in medicine, Vol.24(5), pp.1062-1072

2022-05

DOI: https://doi.org/10.1016/j.gim.2022.01.022

PMID: 35331649

Appears in Miller School of Medicine - Latest Publications

Abstract

Clinical translation

Implementation

Individualized medicine

Pharmacogenomics

Pre-emptive clinical DNA sequencing

The Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large cohort. We also generated the tools and resources necessary for clinical PGx implementation and identified challenges that need to be overcome. Furthermore, we measured the frequency of both common genetic variation for which clinical guidelines already exist and rare variation that could be detected by DNA sequencing, rather than genotyping. Targeted oligonucleotide-capture sequencing of 77 pharmacogenes was performed using DNA from 10,077 consented Mayo Clinic Biobank volunteers. The resulting predicted drug response–related phenotypes for 13 genes, including CYP2D6 and HLA, affecting 21 drug–gene pairs, were deposited preemptively in the Mayo electronic health record. For the 13 pharmacogenes of interest, the genomes of 79% of participants carried clinically actionable variants in 3 or more genes, and DNA sequencing identified an average of 3.3 additional conservatively predicted deleterious variants that would not have been evident using genotyping. Implementation of preemptive rather than reactive and sequence-based rather than genotype-based PGx prescribing revealed nearly universal patient applicability and required integrated institution-wide resources to fully realize individualized drug therapy and to show more efficient use of health care resources.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.597 BRCA1
Web Of Science research areas: Genetics & Heredity
ESI research areas: Clinical Medicine

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Title: Implementation of preemptive DNA sequence–based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study
Creators: Liewei Wang - Mayo Clinic
Steven E. Scherer - Baylor College of Medicine
Suzette J. Bielinski - Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Donna M. Muzny - Baylor College of Medicine
Leila A. Jones - Mayo Clinic
John Logan Black - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
Ann M. Moyer - Mayo Clinic
Jyothsna Giri - Mayo Clinic
Richard R. Sharp - Mayo Clinic in Florida
Eric T. Matey - Department of Pharmacy, Mayo Clinic, Rochester, MN.
Jessica A. Wright - Department of Pharmacy, Mayo Clinic, Rochester, MN
Lance J. Oyen - Department of Pharmacy, Mayo Clinic, Rochester, MN.
Wayne T. Nicholson - Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN
Mathieu Wiepert - Department of Information Technology, Mayo Clinic, Rochester, MN.
Terri Sullard - Mayo Clinic
Timothy B. Curry - Mayo Clinic
Carolyn R. Rohrer Vitek - Center for Individualized Medicine, Mayo Clinic, Rochester, MN
Tammy M. McAllister - Mayo Clinic
Jennifer L. St. Sauver - Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
Pedro J. Caraballo - Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Konstantinos N. Lazaridis - Mayo Clinic
Eric Venner - Baylor College of Medicine
Xiang Qin - Baylor College of Medicine
Jianhong Hu - Baylor College of Medicine
Christie L. Kovar - Baylor College of Medicine
Viktoriya Korchina - Baylor College of Medicine
Kimberly Walker - Baylor College of Medicine
HarshaVardhan Doddapaneni - Baylor College of Medicine
Tsung-Jung Wu - Baylor College of Medicine
Ritika Raj - Baylor College of Medicine
Shawn Denson - Baylor College of Medicine
Wen Liu - Baylor College of Medicine
Gauthami Chandanavelli - Baylor College of Medicine
Lan Zhang - Baylor College of Medicine
Qiaoyan Wang - Baylor College of Medicine
Divya Kalra - Baylor College of Medicine
Mary Beth Karow - Mayo Clinic
Kimberley J. Harris - Mayo Clinic
Hugues Sicotte - Mayo Clinic
Sandra E. Peterson - Mayo Clinic
Amy E. Barthel - Mayo Clinic
Brenda E. Moore - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
Jennifer M. Skierka - Mayo Clinic
Michelle L. Kluge - Mayo Clinic
Katrina E. Kotzer - Mayo Clinic
Karen Kloke - Mayo Clinic
Jessica M. Vander Pol - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
Heather Marker - Mayo Clinic
Joseph A. Sutton - Department of Information Technology, Mayo Clinic, Rochester, MN
Adrijana Kekic - Department of Pharmacy, Mayo Clinic, Phoenix, AZ.
Ashley Ebenhoh - Department of Pharmacy, Mayo Clinic, Rochester, MN.
Dennis M. Bierle - Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Michael J. Schuh - Department of Pharmacy, Mayo Clinic, Jacksonville, FL
Christopher Grilli - Department of Pharmacy, Mayo Clinic, Phoenix, AZ.
Sara Erickson - Mayo Clinic in Florida
Audrey Umbreit - Mayo Clinic Health System
Leah Ward - Mayo Clinic in Florida
Sheena Crosby - Mayo Clinic in Florida
Eric A. Nelson - Department of Pharmacy, Mayo Clinic, Phoenix, AZ
Sharon Levey - Department of Clinical Genomics, Mayo Clinic, Scottsdale, AZ.
Michelle Elliott - Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
Steve G. Peters - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Naveen Pereira - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Mark Frye - Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
Fadi Shamoun - Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ.
Matthew P. Goetz - Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN
Iftikhar J. Kullo - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Robert Wermers - Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Jan A. Anderson - Department of Pharmacy, Mayo Clinic, Rochester, MN
Christine M. Formea - Department of Pharmacy, Mayo Clinic, Rochester, MN.
Razan M. El Melik - Department of Pharmacy, Mayo Clinic, Rochester, MN.
John D. Zeuli - Department of Pharmacy, Mayo Clinic, Rochester, MN.
Joseph R. Herges - Department of Pharmacy, Mayo Clinic, Rochester, MN.
Carrie A. Krieger - Department of Pharmacy, Mayo Clinic, Rochester, MN.
Robert W. Hoel - Department of Pharmacy, Mayo Clinic, Rochester, MN.
Jodi L. Taraba - Department of Pharmacy, Mayo Clinic, Rochester, MN.
Scott R. St. Thomas - Center for Individualized Medicine, Mayo Clinic, Rochester, MN
Imad Absah - Mayo Clinic in Florida
Matthew E. Bernard - Department of Family Medicine, Mayo Clinic, Rochester, MN.
Stephanie R. Fink - Division of Community Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Andrea Gossard - Mayo Clinic in Arizona
Pamela L. Grubbs - Mayo Clinic in Florida
Therese M. Jacobson - Mayo Clinic in Florida
Paul Takahashi - Division of Community Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Sharon C. Zehe - Legal Department, Mayo Clinic, Rochester, MN.
Susan Buckles - Department of Public Affairs, Mayo Clinic, Rochester, MN.
Michelle Bumgardner - Mayo Clinic in Florida
Colette Gallagher - Department of Public Affairs, Mayo Clinic, Rochester, MN.
Kelliann Fee-Schroeder - Mayo Clinic
Nichole R. Nicholas - Mayo Clinic
Melody L. Powers - Specim
Ahmed K. Ragab - Mayo Clinic
Darcy M. Richardson - Mayo Clinic
Anthony Stai - Department of Information Technology, Mayo Clinic, Rochester, MN.
Jaymi Wilson - Mayo Clinic
Joel E. Pacyna - Mayo Clinic in Florida
Janet E. Olson - Mayo Clinic in Florida
Erica J. Sutton - Mayo Clinic in Florida
Annika T. Beck - Mayo Clinic in Florida
Caroline Horrow - Mayo Clinic in Florida
Krishna R. Kalari - Mayo Clinic in Florida
Nicholas B. Larson - Mayo Clinic in Florida
Hongfang Liu - Mayo Clinic in Florida
Liwei Wang - Mayo Clinic in Florida
Guilherme S. Lopes - Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
Bijan J. Borah - Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN; Division of Health Care Policy and Research, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Robert R. Freimuth - Mayo Clinic in Florida
Ye Zhu - Mayo Clinic in Arizona
Debra J. Jacobson - Mayo Clinic in Florida
Matthew A. Hathcock - Mayo Clinic in Florida
Sebastian M. Armasu - Mayo Clinic in Florida
Michaela E. McGree - Mayo Clinic in Florida
Ruoxiang Jiang - Mayo Clinic in Florida
Tyler H. Koep - Product Innovation and Engineering (United States, Saint James) - LLC
Jason L. Ross - Product Innovation and Engineering (United States, Saint James) - LLC
Matthew G. Hilden - Product Innovation and Engineering (United States, Saint James) - LLC
Kathleen Bosse - Product Innovation and Engineering (United States, Saint James) - LLC
Bronwyn Ramey - Product Innovation and Engineering (United States, Saint James) - LLC
Isabelle Searcy - Product Innovation and Engineering (United States, Saint James) - LLC
Eric Boerwinkle - The University of Texas Health Science Center at Houston
Richard A. Gibbs - Baylor College of Medicine
Richard M. Weinshilboum - Mayo Clinic
Publication Details: Genetics in medicine, Vol.24(5), pp.1062-1072
Publisher: Elsevier Inc
Comment: "APPROVED for Hu, Jennifer based on https://www.publichealth.med.miami.edu/news/news-releases/2020/miller-schools-dr.-jennifer-hu-named-director-of-public-healths-division-of-epidemiology-and-population-health-sciences/index.html"
Academic Unit: Miller School of Medicine; UMMG Department of Public Health Sciences Research
Language: English
Resource Type: Journal article
PMID: 35331649
Record Identifier: 991031786429502976