Abstract
ABSTRACTCheung HS, Johansen JG, Haughton VM, Nichols TR. In vitro testing for the risk of arachnoiditis from myelographic contrast media. Invest Radiol 1985;20:472–475.The risk of arachnoiditis from aqueous myelographic contrast media has been assayed reliably only in experimental animals. The effect of contrast media on protein and collagen production by fibroblasts in vitro was studied. Iocarmate, metrizamide, and iopamidol added to the culture medium caused cells to produce more protein and collagen. The degree to which the contrast medium stimulated collagen production correlated with the risk of arachnoiditis from the intrathecal use of the contrast medium. In vitro testing appears to be an effective assay for arachnoiditis.
