Interplay between Mitophagy and Inflammasomes in Neurological Disorders

Radhika Kesharwani; Deepaneeta Sarmah; Harpreet Kaur; Leela Mounika; Geetesh Verma; Veeresh Pabbala; Vignesh Kotian; Kiran Kalia; Anupom Borah; Kunjan R Dave; Dileep R Yavagal; Pallab Bhattacharya

doi:10.1021/acschemneuro.9b00117

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Interplay between Mitophagy and Inflammasomes in Neurological Disorders

Journal article

Peer reviewed

Interplay between Mitophagy and Inflammasomes in Neurological Disorders

Radhika Kesharwani, Deepaneeta Sarmah, Harpreet Kaur, Leela Mounika, Geetesh Verma, Veeresh Pabbala, Vignesh Kotian, Kiran Kalia, Anupom Borah, Kunjan R Dave, …

ACS chemical neuroscience, Vol.10(5), pp.2195-2208

2019-05-15

DOI: https://doi.org/10.1021/acschemneuro.9b00117

PMID: 30917655

Abstract

Brain - metabolism

Animals

Inflammasomes - metabolism

Mitophagy - physiology

Humans

Brain - pathology

Nervous System Diseases - metabolism

Autophagy - physiology

Mitochondria - metabolism

Nervous System Diseases - pathology

Mitophagy and inflammasomes have a pivotal role in the development of neuropathology. Molecular mechanisms behind mitophagy and inflammasomes are well-understood, but lacunae prevail in understanding the crosstalk between them in various neurological disorders. As mitochondrial dysfunction is the prime event in neurodegeneration, the clearance of impaired mitochondria is one of the main tasks for maintaining cell integrity in the majority of neuropathologies. Along with it, inflammasome activation also plays a major role, which is usually followed by mitochondrial dysfunction. The present review highlights basics of autophagy, mitophagy, and inflammasomes and the molecular mechanisms involved, and more importantly, it tries to elaborate the interplay between mitophagy and inflammasomes in various neurological disorders. This will help in upgrading the reader's understanding in exploring the link between mitophagy and inflammasomes, which has dealt with limitations in past studies.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis; 1.25.797 Autophagy
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Medicinal; Neurosciences
ESI research areas: Neuroscience & Behavior

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Details

Title: Interplay between Mitophagy and Inflammasomes in Neurological Disorders
Creators: Radhika Kesharwani - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad, Gandhinagar - 382 355 , Gujarat , India
Deepaneeta Sarmah - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad, Gandhinagar - 382 355 , Gujarat , India
Harpreet Kaur - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad, Gandhinagar - 382 355 , Gujarat , India
Leela Mounika - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad, Gandhinagar - 382 355 , Gujarat , India
Geetesh Verma - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad, Gandhinagar - 382 355 , Gujarat , India
Veeresh Pabbala - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad, Gandhinagar - 382 355 , Gujarat , India
Vignesh Kotian - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad, Gandhinagar - 382 355 , Gujarat , India
Kiran Kalia - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad, Gandhinagar - 382 355 , Gujarat , India
Anupom Borah - Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics , Assam University , Silchar - 788 011 , Assam , India
Kunjan R Dave - Department of Neurology , University of Miami Miller School of Medicine , Miami , Florida 33136 , United States
Dileep R Yavagal - Department of Neurology , University of Miami Miller School of Medicine , Miami , Florida 33136 , United States
Pallab Bhattacharya - Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad, Gandhinagar - 382 355 , Gujarat , India
Publication Details: ACS chemical neuroscience, Vol.10(5), pp.2195-2208
Academic Unit: Miller School of Medicine; UMMG Department of Neurology
Language: English
Resource Type: Journal article
PMID: 30917655
Record Identifier: 991031599090502976