Intracranial haemorrhage induced at arterial pressure in the rat: Part 2: Short term changes in local cerebral blood flow measured by autoradiography

A.D Mendelow; R Bullock; G.M Teasdale; D.I Graham; J McCulloch

doi:10.1080/01616412.1984.11739688

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Intracranial haemorrhage induced at arterial pressure in the rat: Part 2: Short term changes in local cerebral blood flow measured by autoradiography

Journal article

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Intracranial haemorrhage induced at arterial pressure in the rat: Part 2: Short term changes in local cerebral blood flow measured by autoradiography

A.D Mendelow, R Bullock, G.M Teasdale, D.I Graham and J McCulloch

Neurological research (New York), Vol.6(4), pp.189-193

1984-12-01

DOI: https://doi.org/10.1080/01616412.1984.11739688

PMID: 6152313

Abstract

cerebral blood flow

Cerebral haemorrhage

intracranial pressure

cerebral ischaemia

head injury

The regional distribution of blood flow following intracranial haemorrhage at arterial pressure was measured with the 14 C-iodoantipyrine autoradiographic technique in Sprague Dawley Rats. With uncontained haemorrhage, there was a bilateral reduction in cerebral blood flow, associated with a fall in cerebral perfusion pressure. With contained intracerebral haemorrhage there was a profound ipsilateral reduction in flow in the hemisphere adjacent to the haematoma. This study, indicates that extensive cerebral ischaemia occurs immediately after an intracerebral haemorrhage, and that this may be the result of compression of the microcirculation.

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Title: Intracranial haemorrhage induced at arterial pressure in the rat: Part 2: Short term changes in local cerebral blood flow measured by autoradiography
Creators: A.D Mendelow - Departments of Neurosurgery and Neuropathology, Institute of Neurological Sciences and Wellcome Surgical Institute, University of Glasgow, The Southern General Hospital
R Bullock - Departments of Neurosurgery and Neuropathology, Institute of Neurological Sciences and Wellcome Surgical Institute, University of Glasgow, The Southern General Hospital
G.M Teasdale - Departments of Neurosurgery and Neuropathology, Institute of Neurological Sciences and Wellcome Surgical Institute, University of Glasgow, The Southern General Hospital
D.I Graham - Departments of Neurosurgery and Neuropathology, Institute of Neurological Sciences and Wellcome Surgical Institute, University of Glasgow, The Southern General Hospital
J McCulloch - Departments of Neurosurgery and Neuropathology, Institute of Neurological Sciences and Wellcome Surgical Institute, University of Glasgow, The Southern General Hospital
Publication Details: Neurological research (New York), Vol.6(4), pp.189-193
Publisher: Taylor & Francis
Academic Unit: UMMG Dept of Neurological Surgery
Language: English
Resource Type: Journal article
PMID: 6152313
Record Identifier: 991031559212102976