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Knocking down disease with siRNAs
Journal article   Open access  Peer reviewed

Knocking down disease with siRNAs

Derek M Dykxhoorn and Judy Lieberman
Cell (Cambridge), Vol.126(2), pp.231-235
2006-07-28
DOI: https://doi.org/10.1016/j.cell.2006.07.007
PMCID: PMC7125751
PMID: 16873051

Abstract

RNA, Small Interfering - genetics Gene Silencing - drug effects RNA, Small Interfering - pharmacokinetics Humans Infections - therapy RNA, Small Interfering - chemistry Neoplasms - therapy Animals RNA Interference RNA, Small Interfering - therapeutic use RNA, Small Interfering - administration & dosage Drug Delivery Systems - methods Genetic Therapy - methods RNA, Small Interfering - metabolism
Knocking down expression of disease-related genes using small interfering RNAs (siRNAs) has potential for treating a variety of illnesses. This Essay will examine the opportunities for harnessing RNA interference (RNAi) for therapy, as well as the obstacles and possible ways to circumvent them.
url
https://doi.org/10.1016/j.cell.2006.07.007View
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172 Times Cited - Web of Science

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Citation topics
1 Clinical & Life Sciences
1.196 Micro & Long Noncoding RNA
1.196.1705 RNAi
Web Of Science research areas
Biochemistry & Molecular Biology
Cell Biology
ESI research areas
Molecular Biology & Genetics

UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

Source: InCites

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