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Latrogenic platelet dysfunction: an emerging peril
Journal article   Peer reviewed

Latrogenic platelet dysfunction: an emerging peril

Plastic and reconstructive surgery (1963), Vol.55(5), pp.602-605
1975-05
PMID: 1144537

Abstract

Blood Coagulation Disorders - chemically induced Lidocaine - pharmacology Face - surgery Lidocaine - adverse effects Blood Coagulation Disorders - etiology Humans Middle Aged Clofibrate - adverse effects Male Surgery, Plastic - adverse effects Drug Synergism Hematoma Iatrogenic Disease Blood Platelets - drug effects In Vitro Techniques Postoperative Complications Clofibrate - pharmacology
Abnormal bleeding after a face lift was found to be due to a profound interference in platelet function caused by clofibrate and xylocaine acting synergistically. This did not appear to be an idiosyncratic reaction to either of the drugs, as it could be reproduced in vitro by using platelets from normal individuals. Clofibrate is a drug used commonly by persons in the age group requesting face lifts. Beware.

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