Linezolid- and Vancomycin-resistant Enterococcus faecium in Solid Organ Transplant Recipients: Infection Control and Antimicrobial Stewardship Using Whole Genome Sequencing

Lilian Abbo; Bhavarth S Shukla; Amber Giles; Laura Aragon; Adriana Jimenez; Jose F Camargo; Jacques Simkins; Kathleen Sposato; Truc T Tran; Lorena Diaz; Jinnethe Reyes; Rafael Rios; Lina P Carvajal; Javier Cardozo; Maribel Ruiz; Gemma Rosello; Armando Perez Cardona; Octavio Martinez; Giselle Guerra; Thiago Beduschi; Rodrigo Vianna; Cesar A Arias

doi:10.1093/cid/ciy903

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Linezolid- and Vancomycin-resistant Enterococcus faecium in Solid Organ Transplant Recipients: Infection Control and Antimicrobial Stewardship Using Whole Genome Sequencing

Journal article

Open access

Peer reviewed

Linezolid- and Vancomycin-resistant Enterococcus faecium in Solid Organ Transplant Recipients: Infection Control and Antimicrobial Stewardship Using Whole Genome Sequencing

Lilian Abbo, Bhavarth S Shukla, Amber Giles, Laura Aragon, Adriana Jimenez, Jose F Camargo, Jacques Simkins, Kathleen Sposato, Truc T Tran, Lorena Diaz, …

Clinical infectious diseases, Vol.69(2), pp.259-265

2019-07-15

DOI: https://doi.org/10.1093/cid/ciy903

PMCID: PMC6775576

PMID: 30339217

Abstract

whole genome sequencing

organ transplant

E faecium

infection control

and Commentaries

linezolid resistance

A vancomycin-resistant enterococci outbreak occurred in a large organ transplant center and remained undetected due to limitations of conventional testing methods. Whole genome sequencing revealed a subpopulation of organisms harboring the G2576C mutation affecting 23S ribosomal RNA and conferring resistance to linezolid.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.173 Staphylococcus Aureus
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology
ESI research areas: Immunology

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Details

Title: Linezolid- and Vancomycin-resistant Enterococcus faecium in Solid Organ Transplant Recipients: Infection Control and Antimicrobial Stewardship Using Whole Genome Sequencing
Creators: Lilian Abbo - Department of Infection Control and Prevention and Antimicrobial Stewardship Program, Jackson Memorial Hospital
Bhavarth S Shukla - Department of Infection Control and Prevention and Antimicrobial Stewardship Program, Jackson Memorial Hospital
Amber Giles - Department of Pharmacy Practice, School of Pharmacy, Presbyterian College
Laura Aragon - Department of Infection Control and Prevention and Antimicrobial Stewardship Program, Jackson Memorial Hospital
Adriana Jimenez - Department of Infection Control and Prevention and Antimicrobial Stewardship Program, Jackson Memorial Hospital
Jose F Camargo - Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine
Jacques Simkins - Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine
Kathleen Sposato - Department of Infection Control and Prevention and Antimicrobial Stewardship Program, Jackson Memorial Hospital
Truc T Tran - Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, McGovern Medical School, University of Texas Health Science Center at Houston
Lorena Diaz - Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, McGovern Medical School, University of Texas Health Science Center at Houston
Jinnethe Reyes - Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, McGovern Medical School, University of Texas Health Science Center at Houston
Rafael Rios - Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque
Lina P Carvajal - Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque
Javier Cardozo - Department of Infection Control and Prevention and Antimicrobial Stewardship Program, Jackson Memorial Hospital
Maribel Ruiz - Department of Infection Control and Prevention and Antimicrobial Stewardship Program, Jackson Memorial Hospital
Gemma Rosello - Department of Infection Control and Prevention and Antimicrobial Stewardship Program, Jackson Memorial Hospital
Armando Perez Cardona - Department of Pathology and Laboratory Medicine, Department of Surgery, University of Miami Miller School of Medicine
Octavio Martinez - Department of Pathology and Laboratory Medicine, Department of Surgery, University of Miami Miller School of Medicine
Giselle Guerra - Division of Nephrology, Department of Medicine, Department of Surgery, University of Miami Miller School of Medicine
Thiago Beduschi - Division of Liver and Gastrointestinal Transplant Surgery, Department of Surgery, University of Miami Miller School of Medicine
Rodrigo Vianna - Division of Liver and Gastrointestinal Transplant Surgery, Department of Surgery, University of Miami Miller School of Medicine
Cesar A Arias - Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, McGovern Medical School, University of Texas Health Science Center at Houston
Publication Details: Clinical infectious diseases, Vol.69(2), pp.259-265
Publisher: Oxford University Press
Grant note: K24 AI121296 / ; ; ; ; ; ;
Academic Unit: Miller School of Medicine; Miami Transplant Institute; UMMG Department of Pathology; UMMG Department of Surgery; UMMG Dept of Medicine - Infectious Diseases; UMMG Dept of Medicine - Nephrology & Hypertension Div
Language: English
Resource Type: Journal article
PMID: 30339217
PMCID: PMC6775576
Record Identifier: 991031599225102976