Linkage Disequilibrium Inflates Type I Error Rates in Multipoint Linkage Analysis when Parental Genotypes Are Missing

Abee L Boyles; William K Scott; Eden R Martin; Silke Schmidt; Yi-Ju Li; Allison Ashley-Koch; Meredyth P Bass; Michael Schmidt; Margaret A Pericak-Vance; Marcy C Speer; Elizabeth R Hauser

doi:10.1159/000087122

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Linkage Disequilibrium Inflates Type I Error Rates in Multipoint Linkage Analysis when Parental Genotypes Are Missing

Journal article

Open access

Peer reviewed

Linkage Disequilibrium Inflates Type I Error Rates in Multipoint Linkage Analysis when Parental Genotypes Are Missing

Abee L Boyles, William K Scott, Eden R Martin, Silke Schmidt, Yi-Ju Li, Allison Ashley-Koch, Meredyth P Bass, Michael Schmidt, Margaret A Pericak-Vance, Marcy C Speer, …

Human heredity, Vol.59(4), pp.220-227

2005

DOI: https://doi.org/10.1159/000087122

PMCID: PMC1224705

PMID: 16093727

Abstract

Parameter misspecification

False positive rate

Measures of linkage disequilibrium

Linkage disequilibrium

Linkage analysis

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https://doi.org/10.1159/000087122View

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Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.455 Genome-Wide Association Studies
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics

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Details

Title: Linkage Disequilibrium Inflates Type I Error Rates in Multipoint Linkage Analysis when Parental Genotypes Are Missing
Creators: Abee L Boyles - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
William K Scott - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
Eden R Martin - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
Silke Schmidt - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
Yi-Ju Li - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
Allison Ashley-Koch - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
Meredyth P Bass - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
Michael Schmidt - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
Margaret A Pericak-Vance - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
Marcy C Speer - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
Elizabeth R Hauser - Center for Human Genetics, Duke University Medical Center, Durham, N.C., USA
Publication Details: Human heredity, Vol.59(4), pp.220-227
Academic Unit: Miller School of Medicine; John P. Hussman Institute for Human Genomics; UMMG Dept of Human Genetics - Clinical and Translational Genetics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 16093727
PMCID: PMC1224705
Record Identifier: 991031561585602976