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Linking the VPS35 and EIF4G1 Pathways in Parkinson's Disease
Journal article   Open access

Linking the VPS35 and EIF4G1 Pathways in Parkinson's Disease

O.A. Ross, C. Cook and L. Petrucelli
Neuron, Vol.85(1), pp.1-3
2015
DOI: https://doi.org/10.1016/j.neuron.2014.12.045
PMID: 25569341

Abstract

alpha-Synuclein Animals Caenorhabditis elegans Proteins Eukaryotic Initiation Factor-4G Parkinson Disease Saccharomyces cerevisiae Proteins Vesicular Transport Proteins alpha synuclein alpha synuclein Caenorhabditis elegans protein initiation factor 4G Saccharomyces cerevisiae protein vesicular transport protein EIF4G1 gene gene gene deletion gene interaction gene mutation gene overexpression human nerve degeneration nonhuman Parkinson disease pathogenesis pathogenicity Short Survey VPS35 gene yeast animal genetics Parkinson disease
Elucidating the underlying pathogenic pathways in Parkinson's disease will be critical for targeted drug development. In this issue of Neuron, Dhungel etal. (2015) utilize a yeast model to establish a link between VPS35 and EIF4G1 in α-synuclein-related neurodegeneration. © 2015 Elsevier Inc.
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84920722589&doi=10.1016%2fj.neuron.2014.12.045&partnerID=40&md5=cb741f4bc78483e880db5853954f3b34View
url
https://doi.org/10.1016/j.neuron.2014.12.045View
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