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Long‐Term Graft Survival and Visual Outcomes in Deep Anterior Lamellar Keratoplasty (DALK): A Narrative Review
Journal article   Open access   Peer reviewed

Long‐Term Graft Survival and Visual Outcomes in Deep Anterior Lamellar Keratoplasty (DALK): A Narrative Review

Sadegh Ghafarian and Ellen H. Koo
Journal of ophthalmology, Vol.2026(1), p.8120487
2026
PMID: 41737287

Abstract

Review
Deep anterior lamellar keratoplasty (DALK) selectively replaces the scarred or diseased corneal stroma, while preserving healthy endothelium, thus providing an alternative to penetrating keratoplasty (PK) for patients with stromal disorders. Despite its recognized advantages, DALK has not become as widely adopted as anticipated over the past decades. The satisfactory visual outcomes of PK, the lack of standardized DALK techniques, as well as the limited long‐term data on visual and refractive outcomes for both DALK and PK are commonly cited as barriers to its broader implementation. Evidence from long‐term studies indicates that DALK offers superior graft survival and provides a safer intraoperative profile with fewer complications and lower endothelial cell loss, making it the preferred option for stromal diseases with healthy endothelium.
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Long‐Term Graft Survival and Visual Outcomes in Deep Anterior Lamellar Keratoplasty (DALK): A Narrative Review681.14 kBDownloadView
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url
https://pmc.ncbi.nlm.nih.gov/articles/PMC12927906/View

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Collaboration types
Domestic collaboration
International collaboration
Citation topics
1 Clinical & Life Sciences
1.36 Ophthalmology
1.36.141 Corneal and Lens Surgery
Web Of Science research areas
Ophthalmology
ESI research areas
Clinical Medicine

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