Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection

Yolanda Guillén; Marc Noguera-Julian; Javier Rivera; Maria Casadellà; Alexander S Zevin; Muntsa Rocafort; Mariona Parera; Cristina Rodríguez; Marçal Arumí; Jorge Carrillo; Beatriz Mothe; Carla Estany; Josep Coll; Isabel Bravo; Cristina Herrero; Jorge Saz; Guillem Sirera; Ariadna Torrella; Jordi Navarro; Manuel Crespo; Eugènia Negredo; Christian Brander; Julià Blanco; Maria Luz Calle; Nichole R Klatt; Bonaventura Clotet; Roger Paredes

doi:10.1038/s41385-018-0083-7

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Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection

Journal article

Open access

Peer reviewed

Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection

Yolanda Guillén, Marc Noguera-Julian, Javier Rivera, Maria Casadellà, Alexander S Zevin, Muntsa Rocafort, Mariona Parera, Cristina Rodríguez, Marçal Arumí, Jorge Carrillo, …

Mucosal immunology, Vol.12(1), pp.232-246

2019-01

DOI: https://doi.org/10.1038/s41385-018-0083-7

PMID: 30171206

Abstract

Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal inflammation. Using a similar approach in 156 subjects with different HIV-1 phenotypes, we found a strong, independent, dose-effect association between nadir CD4+ T-cell counts and LGC. As in other diseases involving intestinal inflammation, the gut microbiomes of subjects with LGC were enriched in gram-negative Bacteroides, acetogenic bacteria and Proteobacteria, which are able to metabolize reactive oxygen and nitrogen species; and were depleted in oxygen-sensitive methanogenic archaea and sulfate-reducing bacteria. Interestingly, subjects with LGC also showed increased butyrate levels in direct fecal measurements, consistent with enrichment in Roseburia intestinalis despite reductions in other butyrate producers. The microbiomes of subjects with LGC were also enriched in bacterial virulence factors, as well as in genes associated with beta-lactam, lincosamide, tetracycline, and macrolide resistance. Thus, low nadir CD4+ T-cell counts, rather than HIV-1 serostatus per se, predict the presence of gut dysbiosis in HIV-1 infected subjects. Such dysbiosis does not display obvious HIV-specific features; instead, it shares many similarities with other diseases featuring gut inflammation.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.120 Inflammatory Bowel Diseases & Infections; 1.120.384 Gut Microbiota
Web Of Science research areas: Immunology
ESI research areas: Immunology

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Title: Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection
Creators: Yolanda Guillén - Universitat Autònoma de Barcelona, Bellaterra, 08193, Catalonia, Spain
Marc Noguera-Julian - Universitat de Vic-Universitat Central de Catalunya, C. Sagrada Família 7, Vic, 08500, Catalonia, Spain
Javier Rivera - Universitat de Vic-Universitat Central de Catalunya, C. Sagrada Família 7, Vic, 08500, Catalonia, Spain
Maria Casadellà - Universitat Autònoma de Barcelona, Bellaterra, 08193, Catalonia, Spain
Alexander S Zevin - University of Washington, 3018 Western Avenue, Seattle, WA, 98121, USA
Muntsa Rocafort - Universitat Autònoma de Barcelona, Bellaterra, 08193, Catalonia, Spain
Mariona Parera - irsiCaixa AIDS Research Institute, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Cristina Rodríguez - irsiCaixa AIDS Research Institute, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Marçal Arumí - irsiCaixa AIDS Research Institute, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Jorge Carrillo - Universitat Autònoma de Barcelona, Bellaterra, 08193, Catalonia, Spain
Beatriz Mothe - Infectious Diseases Service & Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Carla Estany - Infectious Diseases Service & Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Josep Coll - Infectious Diseases Service & Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Isabel Bravo - Infectious Diseases Service & Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Cristina Herrero - Infectious Diseases Service & Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Jorge Saz - BCN Checkpoint, Carrer del Comte Borrell, 164, Barcelona, 08015, Catalonia, Spain
Guillem Sirera - Infectious Diseases Service & Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Ariadna Torrella - Infectious Diseases Unit, Hospital Universitari Vall d'Hebrón, Passeig de la Vall d'Hebrón, 119-129, Barcelona, 08035, Catalonia, Spain
Jordi Navarro - Infectious Diseases Unit, Hospital Universitari Vall d'Hebrón, Passeig de la Vall d'Hebrón, 119-129, Barcelona, 08035, Catalonia, Spain
Manuel Crespo - Infectious Diseases Unit, Internal Medicine Department, Complexo Hospitalario Universitario, Vigo. IIS Galicia Sur, Estrada de Clara Campoamor, 341, Vigo, 36312, Pontevedra, Spain
Eugènia Negredo - Infectious Diseases Service & Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Christian Brander - Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, Barcelona, 08010, Catalonia, Spain
Julià Blanco - Universitat de Vic-Universitat Central de Catalunya, C. Sagrada Família 7, Vic, 08500, Catalonia, Spain
Maria Luz Calle - Universitat de Vic-Universitat Central de Catalunya, C. Sagrada Família 7, Vic, 08500, Catalonia, Spain
Nichole R Klatt - University of Washington, 3018 Western Avenue, Seattle, WA, 98121, USA
Bonaventura Clotet - Infectious Diseases Service & Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain
Roger Paredes - Infectious Diseases Service & Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, Badalona, 08916, Catalonia, Spain. rparedes@irsicaixa.es
Publication Details: Mucosal immunology, Vol.12(1), pp.232-246
Academic Unit: UMMG Department of Pediatrics
Language: English
Resource Type: Journal article
PMID: 30171206
Record Identifier: 991031614816502976