MIF-I's differential actions as an opiate antagonist

Abba J Kastin; Richard D Olson; Rudolph H Ehrensing; Matthew C Berzas; Andrew V Schally; David H Coy

doi:10.1016/0091-3057(79)90270-3

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MIF-I's differential actions as an opiate antagonist

Journal article

Peer reviewed

MIF-I's differential actions as an opiate antagonist

Abba J Kastin, Richard D Olson, Rudolph H Ehrensing, Matthew C Berzas, Andrew V Schally and David H Coy

Pharmacology, biochemistry and behavior, Vol.11(6), pp.721-723

1979

DOI: https://doi.org/10.1016/0091-3057(79)90270-3

PMID: 43981

Abstract

Analgesia

Food intake

MIF-I

Opiate

Peptide

Receptor

Vas deferens

The effects of MIF-I (Pro-Leu-Gly-NH 2) were examined in three experimental conditions in which the opiate antagonist naloxone is active. MIF-I was found to block the analgesic effects of enkephalins and also morphine in the tail-flick test but not in the vas deferens assay. Unlike naloxone, MIF-I did not seem to reduce food intake in VMH-lesioned rats. The results suggest the possibility that MIF-I may represent a class of naturally occurring opiate antagonists with varying activities in independent situations.

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Details

Title: MIF-I's differential actions as an opiate antagonist
Creators: Abba J Kastin - Veterans Administration Medical Center, Tulane University School of Medicine, University of New Orleans, USA
Richard D Olson - Veterans Administration Medical Center, Tulane University School of Medicine, University of New Orleans, USA
Rudolph H Ehrensing - Veterans Administration Medical Center, Tulane University School of Medicine, University of New Orleans, USA
Matthew C Berzas - Veterans Administration Medical Center, Tulane University School of Medicine, University of New Orleans, USA
Andrew V Schally - Veterans Administration Medical Center, Tulane University School of Medicine, University of New Orleans, USA
David H Coy - Veterans Administration Medical Center, Tulane University School of Medicine, University of New Orleans, USA
Publication Details: Pharmacology, biochemistry and behavior, Vol.11(6), pp.721-723
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 43981
Record Identifier: 991031614049902976