Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells

I. Masuho; K. Xie; K.A. Martemyanov

doi:10.1074/jbc.M113.462283

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Journal article

Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells

I. Masuho, K. Xie and K.A. Martemyanov

Journal of Biological Chemistry, Vol.288(35), pp.25129-25142

2013

DOI: https://doi.org/10.1074/jbc.M113.462283

PMID: 23857581

Abstract

Animals

Carrier Proteins

Corpus Striatum

GTP-Binding Protein alpha Subunits, Gi-Go

HEK293 Cells

Humans

Multiprotein Complexes

Nerve Tissue Proteins

Neurons

Receptors, Dopamine D2

Receptors, Opioid, mu

RGS Proteins

Signal Transduction

Macromolecules

G Protein-coupled Receptors (GPCR)

G Proteins

Neurons

RGS Proteins

Signal Transduction

G protein coupled receptor

guanine nucleotide binding protein

guanosine triphosphatase activating protein

inhibitory guanine nucleotide binding protein

RGS protein

RGS7 protein

RGS9-2 protein

stimulatory guanine nucleotide binding protein

unclassified drug

G protein

Living cell

Macromolecular composition

Protein complexes

Striatum

article

bioluminescence resonance energy transfer

controlled study

corpus striatum

dissociation

enzyme activity

human

human cell

macromolecule

priority journal

protein expression

protein family

receptor down regulation

Proteins

Background: RGS7 and RGS9-2 regulate G protein signaling in the striatum, but the selectivity of their action is largely unknown. Results: RGS protein complexes show distinct patterns of receptor and G protein selectivity. Conclusion: Macromolecular composition dictates receptor and G protein selectivity of the RGS7 and RGS9-2 protein complexes. Significance: These data demonstrate novel mechanisms contributing to the regulation of striatal G protein signaling. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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Citation topics: 1 Clinical & Life Sciences; 1.159 Membrane Channels & Receptors; 1.159.426 GPCR Signaling
Web Of Science research areas: Biochemistry & Molecular Biology
ESI research areas: Biology & Biochemistry

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Title: Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells
Creators: I. Masuho - Scripps Research Institute
K. Xie - Scripps Research Institute
K.A. Martemyanov - Scripps Research Institute
Publication Details: Journal of Biological Chemistry, Vol.288(35), pp.25129-25142
Grant note: National Institutes of Health: DA021743, DA026405
This work was supported, in whole or in part, by National Institutes of Health Grants DA021743 and DA026405.
Comment: Export Date: 24 October 2025; Cited By: 46; CODEN: JBCHA
Academic Unit: Physiology and Biophysics Research; Miller School of Medicine
Resource Type: Journal article
PMID: 23857581
Record Identifier: 991032828750202976