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Making the most of what you've got: optimizing residual OXPHOS function in mitochondrial diseases
Journal article   Open access  Peer reviewed

Making the most of what you've got: optimizing residual OXPHOS function in mitochondrial diseases

Carlos T Moraes
EMBO molecular medicine, Vol.1(8-9), pp.357-359
2009-11
DOI: https://doi.org/10.1002/emmm.200900049
PMCID: PMC3378150
PMID: 20049740

Abstract

Cyclic AMP-Dependent Protein Kinases - metabolism Mitochondrial Diseases - enzymology Mitochondria - enzymology Adenosine Triphosphate - metabolism Humans Oxidative Phosphorylation Mitochondria - pathology Electron Transport Complex IV - metabolism
Patients affected by mitochondrial OXPHOS disorders are still faced with a grim lack of therapeutic options. In this Closeup, Carlos Moraes revisits the recent data by Giovanni Manfredi on PKA's functions in the mitochondria and now its modulation can improve respiration and ATP production in COX-defective cells.
url
https://doi.org/10.1002/emmm.200900049View
Published (Version of record) Open

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2 Times Cited - Web of Science

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Citation topics
1 Clinical & Life Sciences
1.197 Molecular & Cell Biology - Mitochondria
1.197.564 Mitochondrial DNA
Web Of Science research areas
Medicine, Research & Experimental
ESI research areas
Clinical Medicine

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#3 Good Health and Well-Being

Source: InCites

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