Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Ashok Agarwal; Neel Parekh; Manesh Kumar Panner Selvam; Ralf Henkel; Rupin Shah; Sheryl T Homa; Ranjith Ramasamy; Edmund Ko; Kelton Tremellen; Sandro Esteves; Ahmad Majzoub; Juan G Alvarez; David K Gardner; Channa N Jayasena; Jonathan W Ramsay; Chak Lam Cho; Ramadan Saleh; Denny Sakkas; James M Hotaling; Scott D Lundy; Sarah Vij; Joel Marmar; Jaime Gosalvez; Edmund Sabanegh; Hyun Jun Park; Armand Zini; Parviz Kavoussi; Sava Micic; Ryan Smith; Gian Maria Busetto; Mustafa Emre Bakırcıoğlu; Gerhard Haidl; Giancarlo Balercia; Nicolás Garrido Puchalt; Moncef Ben-Khalifa; Nicholas Tadros; Jackson Kirkman-Browne; Sergey Moskovtsev; Xuefeng Huang; Edson Borges; Daniel Franken; Natan Bar-Chama; Yoshiharu Morimoto; Kazuhisa Tomita; Vasan Satya Srini; Willem Ombelet; Elisabetta Baldi; Monica Muratori; Yasushi Yumura; Sandro La Vignera; Raghavender Kosgi; Marlon P Martinez; Donald P Evenson; Daniel Suslik Zylbersztejn; Matheus Roque; Marcello Cocuzza; Marcelo Vieira; Assaf Ben-Meir; Raoul Orvieto; Eliahu Levitas; Amir Wiser; Mohamed Arafa; Vineet Malhotra; Sijo Joseph Parekattil; Haitham Elbardisi; Luiz Carvalho; Rima Dada; Christophe Sifer; Pankaj Talwar; Ahmet Gudeloglu; Ahmed M A Mahmoud; Khaled Terras; Chadi Yazbeck; Bojanic Nebojsa; Damayanthi Durairajanayagam; Ajina Mounir; Linda G Kahn; Saradha Baskaran; Rishma Dhillon Pai; Donatella Paoli; Kristian Leisegang; Mohamed Reza Moein; Sonia Malik; Onder Yaman; Luna Samanta; Fouad Bayane; Sunil K Jindal; Muammer Kendirci; Baris Altay; Dragoljub Perovic; Avi Harlev

doi:10.5534/wjmh.190055

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Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

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Peer reviewed

Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Ashok Agarwal, Neel Parekh, Manesh Kumar Panner Selvam, Ralf Henkel, Rupin Shah, Sheryl T Homa, Ranjith Ramasamy, Edmund Ko, Kelton Tremellen, Sandro Esteves, …

The world journal of men's health, Vol.37(3), pp.296-312

2019-09

DOI: https://doi.org/10.5534/wjmh.190055

PMCID: PMC6704307

PMID: 31081299

Abstract

Oxidative stress

Oxidation reduction potential

Infertility, male

MOSI

Semen

Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.81 Reproductive Biology; 1.81.176 Spermatozoa
Web Of Science research areas: Andrology; Health Care Sciences & Services; Urology & Nephrology
ESI research areas: Clinical Medicine

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Title: Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
Creators: Ashok Agarwal - Department of Urology, Cleveland Clinic, Cleveland, OH, USA. agarwaa@ccf.org
Neel Parekh - Department of Urology, Cleveland Clinic, Cleveland, OH, USA
Manesh Kumar Panner Selvam - Department of Urology, Cleveland Clinic, Cleveland, OH, USA
Ralf Henkel - Department of Medical Bioscience, University of the Western Cape, Cape Town, South Africa
Rupin Shah - Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India
Sheryl T Homa - School of Biosciences, University of Kent, Canterbury, UK
Ranjith Ramasamy - Department of Urology, University of Miami, Miami, FL, USA
Edmund Ko - Department of Urology, Loma Linda University Health, Loma Linda, CA, USA
Kelton Tremellen - Department of Obstetrics Gynaecology and Reproductive Medicine, Flinders University, Bedford Park, Australia
Sandro Esteves - Faculty of Health, Aarhus University, Aarhus, Denmark
Ahmad Majzoub - Department of Urology, Hamad Medical Corporation and Weill Cornell Medicine-Qatar, Doha, Qatar
Juan G Alvarez - Centro Androgen, La Coruña, Spain and Harvard Medical School, Boston, MA, USA
David K Gardner - School of BioSciences, University of Melbourne, Parkville, Australia
Channa N Jayasena - Department of Andrology, Hammersmith Hospital, London, UK
Jonathan W Ramsay - Department of Andrology, Hammersmith Hospital, London, UK
Chak Lam Cho - Department of Surgery, Union Hospital, Shatin, Hong Kong
Ramadan Saleh - Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt
Denny Sakkas - Boston IVF, Waltham, MA, USA
James M Hotaling - Department of Urology, University of Utah, Salt Lake City, UT, USA
Scott D Lundy - Department of Urology, Cleveland Clinic, Cleveland, OH, USA
Sarah Vij - Department of Urology, Cleveland Clinic, Cleveland, OH, USA
Joel Marmar - Cooper University Hospital, Camden, NJ, USA
Jaime Gosalvez - Departamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain
Edmund Sabanegh - Department of Urology, Cleveland Clinic, Cleveland, OH, USA
Hyun Jun Park - Medical Research Institute of Pusan National University Hospital, Busan, Korea
Armand Zini - Department of Surgery, McGill University, Montreal, QC, Canada
Parviz Kavoussi - Austin Fertility & Reproductive Medicine/Westlake IVF, Austin, TX, USA
Sava Micic - Uromedica Polyclinic, Kneza Milosa, Belgrade, Serbia
Ryan Smith - Department of Urology, University of Virginia, Charlottesville, VA, USA
Gian Maria Busetto - Sapienza University of Rome, Rome, Italy
Mustafa Emre Bakırcıoğlu - Istanbul Florence Nightingale Hospital, Istanbul, Turkey
Gerhard Haidl - Department of Dermatology, University Hospital Bonn, Bonn, Germany
Giancarlo Balercia - Division of Endocrinology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Umberto I Hospital, Ancona, Italy
Nicolás Garrido Puchalt - IVI Foundation Edificio Biopolo - Instituto de Investigación Sanitaria la Fe, Valencia, Spain
Moncef Ben-Khalifa - University Hospital, School of Médicine and PERITOX Laboratory, Amiens, France
Nicholas Tadros - Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA
Jackson Kirkman-Browne - The Birmingham Women's Fertility Centre, Birmingham Women's and Children's NHS Foundation Trust, Mindelsohn Drive, Edgbaston, UK
Sergey Moskovtsev - Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada
Xuefeng Huang - Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Edson Borges - Fertility Medical Group, São Paulo, Brazil
Daniel Franken - Department of Obstetrics & Gynecology, Andrology Unit Faculties of Health Sciences, Tygerberg Hospital, Tygerberg, South Africa
Natan Bar-Chama - Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Yoshiharu Morimoto - IVF Japan Group, Horac Grand Front Osaka Clinic, Osaka, Japan
Kazuhisa Tomita - IVF Japan Group, Horac Grand Front Osaka Clinic, Osaka, Japan
Vasan Satya Srini - Manipal Fertility, Bangalore, India
Willem Ombelet - Hasselt University, Biomedical Research Institute, Diepenbeek, Belgium
Elisabetta Baldi - Department of Experimental and Clinical Medicine, Center of Excellence DeNothe, University of Florence, Italy
Monica Muratori - Department of Experimental and Clinical Biomedical Sciences "Mario Serio", Unit of Sexual Medicine and Andrology, Center of Excellence DeNothe, University of Florence, Florence, Italy
Yasushi Yumura - Department of Urology, Reproduction Center, Yokohama City University Medical Center, Yokohama, Japan
Sandro La Vignera - Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
Raghavender Kosgi - Androbest Andrology & Urology Center, Hyderabad, India
Marlon P Martinez - Section of Urology, University of Santo Tomas Hospital, Manila, Philippines
Donald P Evenson - SCSA Diagnostics, Brookings, SD, USA
Daniel Suslik Zylbersztejn - Fleury Group and Hospital Israelita Albert Einstein, São Paulo, Brazil
Matheus Roque - Origen, Center for Reproductive Medicine, Rio de Janeiro, Brazil
Marcello Cocuzza - Department of Urology, University of São Paulo (USP), Brazil
Marcelo Vieira - Head of Male Infertility Division, Andrology Department, Brazilian Society of Urology, Rio de Janeiro, Brazil
Assaf Ben-Meir - Fertility and IVF Unit, Department of Obstetrics and Gynecology, Hebrew-University Hadassah Medical Center, Jerusalem, Israel
Raoul Orvieto - Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
Eliahu Levitas - Soroka University Medical Center, Ben-Gurion University of the Negev Beer-Sheva, Beersheba, Israel
Amir Wiser - Sackler Medicine School, Tel Aviv University, Tel Aviv, Israel
Mohamed Arafa - Department of Urology, Hamad Medical Corporation, Doha, Qatar
Vineet Malhotra - Department of Andrology and Urology, Diyos Hospital, New Delhi, India
Sijo Joseph Parekattil - University of Central Florida, Orlando, FL, USA
Haitham Elbardisi - Department of Urology, Hamad Medical Corporation, Doha, Qatar
Luiz Carvalho - College Institute of Clinical Research and Teaching Development, São Paulo, Brazil
Rima Dada - Lab for Molecular Reproduction and Genetics, Anatomy, All India Institute of Medical Sciences, New Delhi, India
Christophe Sifer - Department of Reproductive Biology, Hôpitaux Universitaires Paris Seine Saint-Denis, Bondy, France
Pankaj Talwar - Department of Reproductive Medicine and Embryology, Manipal Hospital, New Delhi, India
Ahmet Gudeloglu - Department of Urology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Ahmed M A Mahmoud - Department of Endocrinology/ Andrology, University Hospital Ghent, Ghent, Belgium
Khaled Terras - Department of Reproductive Medicine, Hannibal International Clinic, Tunis, Tunisia
Chadi Yazbeck - Department of Obstetrics, Gynecology and Reproductive Medicine, Pierre Cherest and Hartman Clinics, Paris, France
Bojanic Nebojsa - Clinic of Urology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Damayanthi Durairajanayagam - Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, Selangor, Malaysia
Ajina Mounir - Department of Embryology, Faculty of Medicine, University of Sousse, Sousse, Tunisia
Linda G Kahn - Department of Pediatrics, New York University School of Medicine, New York, NY, USA
Saradha Baskaran - American Center for Reproductive Medicine, Cleveland Clinic, OH, USA
Rishma Dhillon Pai - Department of Obstetrics and Gynaecology, Lilavati Hospital and Research Centre, Mumbai, India
Donatella Paoli - Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
Kristian Leisegang - School of Natural Medicine, University of the Western Cape, Cape Town, South Africa
Mohamed Reza Moein - Department of Andrology, Shahid Sadoughi Medical University, Yazd, Iran
Sonia Malik - Southend Fertility & IVF, Delhi, India
Onder Yaman - Department of Urology, School of Medicine, University of Ankara, Ankara, Turkey
Luna Samanta - Redox Biology Laboratory, Department of Zoology and Center of Excellence in Environment and Public Health, Ravenshaw University, Cutrack, India
Fouad Bayane - Marrakech Fertility Institute, Marrakech, Morocco
Sunil K Jindal - Jindal Hospital, Meerut, India
Muammer Kendirci - Department of Urology, Istinye University Faculty of Medicine, Liv Hospital Ulus, Istanbul, Turkey
Baris Altay - Department of Urology, Ege University School of Medicine, İzmir, Turkey
Dragoljub Perovic - Center of Urology, CODRA Hospital, Podgorica, Montenegro
Avi Harlev - Fertility and IVF Unit, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
Publication Details: The world journal of men's health, Vol.37(3), pp.296-312
Grant note: K99 ES030403 / NIEHS NIH HHS PDF-2017-10-098 / Department of Health American Center for Reproductive Medicine
Academic Unit: Miller School of Medicine; UMMG Department of Urology
Language: English
Resource Type: Journal article
PMID: 31081299
PMCID: PMC6704307
Record Identifier: 991031597609102976