Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans

Jorge R Oksenberg; Lisa F Barcellos; Bruce A. C Cree; Sergio E Baranzini; Teodorica L Bugawan; Omar Khan; Robin R Lincoln; Amy Swerdlin; Emmanuel Mignot; Ling Lin; Douglas Goodin; Henry A Erlich; Silke Schmidt; Glenys Thomson; David E Reich; Margaret A Pericak-Vance; Jonathan L Haines; Stephen L Hauser

doi:10.1086/380997

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Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans

Journal article

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Peer reviewed

Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans

Jorge R Oksenberg, Lisa F Barcellos, Bruce A. C Cree, Sergio E Baranzini, Teodorica L Bugawan, Omar Khan, Robin R Lincoln, Amy Swerdlin, Emmanuel Mignot, Ling Lin, …

American journal of human genetics, Vol.74(1), pp.160-167

2004-01

DOI: https://doi.org/10.1086/380997

PMCID: PMC1181903

PMID: 14669136

Abstract

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An underlying complex genetic susceptibility exists in multiple sclerosis (MS), and an association with the HLA-DRB1*1501-DQB1*0602 haplotype has been repeatedly demonstrated in high-risk (northern European) populations. It is unknown whether the effect is explained by the HLA-DRB1 or the HLA-DQB1 gene within the susceptibility haplotype, which are in strong linkage disequilibrium (LD). African populations are characterized by greater haplotypic diversity and distinct patterns of LD compared with northern Europeans. To better localize the HLA gene responsible for MS susceptibility, case-control and family-based association studies were performed for DRB1 and DQB1 loci in a large and well-characterized African American data set. A selective association with HLA-DRB1*15 was revealed, indicating a primary role for the DRB1 locus in MS independent of DQB1*0602 . This finding is unlikely to be solely explained by admixture, since a substantial proportion of the susceptibility chromosomes from African American patients with MS displayed haplotypes consistent with an African origin.

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Collaboration types: Industry collaboration; Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics

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Title: Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans
Creators: Jorge R Oksenberg - Department of Neurology, University of California at San Francisco, San Francisco
Lisa F Barcellos - Department of Neurology, University of California at San Francisco, San Francisco
Bruce A. C Cree - Department of Neurology, University of California at San Francisco, San Francisco
Sergio E Baranzini - Department of Neurology, University of California at San Francisco, San Francisco
Teodorica L Bugawan - Department of Neurology, University of California at San Francisco, San Francisco
Omar Khan - Department of Neurology, University of California at San Francisco, San Francisco
Robin R Lincoln - Department of Neurology, University of California at San Francisco, San Francisco
Amy Swerdlin - Department of Neurology, University of California at San Francisco, San Francisco
Emmanuel Mignot - Department of Neurology, University of California at San Francisco, San Francisco
Ling Lin - Department of Neurology, University of California at San Francisco, San Francisco
Douglas Goodin - Department of Neurology, University of California at San Francisco, San Francisco
Henry A Erlich - Department of Neurology, University of California at San Francisco, San Francisco
Silke Schmidt - Department of Neurology, University of California at San Francisco, San Francisco
Glenys Thomson - Department of Neurology, University of California at San Francisco, San Francisco
David E Reich - Department of Neurology, University of California at San Francisco, San Francisco
Margaret A Pericak-Vance - Department of Neurology, University of California at San Francisco, San Francisco
Jonathan L Haines - Department of Neurology, University of California at San Francisco, San Francisco
Stephen L Hauser - Department of Neurology, University of California at San Francisco, San Francisco
Publication Details: American journal of human genetics, Vol.74(1), pp.160-167
Publisher: The American Society of Human Genetics
Academic Unit: Miller School of Medicine; John P. Hussman Institute for Human Genomics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 14669136
PMCID: PMC1181903
Record Identifier: 991031563013102976