References: Hanneman, S.K.G., Ingersoll, G.L., Knebel, A.R., Shekleton, M.E., Burns, S.M., Clochesy, J.M., Weaning from short-term mechanical ventilation: a review (1994) Am J Crit Care., 3, pp. 421-441;
Nevins, M.L., Epstein, S.K., Predictors of outcome for patients with COPD requiring invasive mechanical ventilation (2001) Chest., 119, pp. 1840-1849;
Lone, N.I., Walsh, T.S., Prolonged mechanical ventilation in critically ill patients: epidemiology, outcomes and modeling the potential cost consequences of establishing a regional weaning unit (2011) Crit Care., 15, p. R102;
Nelson, J.E., Cox, C.E., Hope, A.A., Harson, S.S., Chronic critical illness (2010) Am J Respir Crit Care Med., 182, pp. 446-454;
(1991) A Study of Chronic Ventilator Patients in the Hospital., , Dallas, TX: AARC;
Carno, M.A., Clochesy, J.M., Carcillo, J., Sereika, S.M., Relationship among serum albumin, TNF-α and IL-6 levels in adults requiring mechanical ventilatory support [abstract] (1999) Crit Care Med., 27, p. A160;
Zergeroglu, M.A., McKenzie, M.J., Shanely, R.A., Gammeren, D.V., DeRuisseau, K.C., Powers, S.K., Mechanical ventilation-induced oxidative stress in the diaphragm (2003) J Appl Physiol., 95, pp. 1116-1124;
Falk, D.J., DeRuiseau, K.C., Van Gammeren, D.L., Deering, M.A., Kavazis, A.N., Powers, S.K., Mechanical ventilation promotes redox status alterations in the diaphragm (2006) J Appl Physiol., 101, pp. 1017-1024;
McClung, J.M., Kavazis, A.N., Whidden, M.A., Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB-Akt) signalling (2007) J Physiol., 585, pp. 203-215;
Levine, S., Nguyen, T., Taylor, N., Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans (2008) N Engl J Med., 358, pp. 1327-1335;
Kavazis, A.N., Talbert, E.E., Smuder, A.J., Hudson, M.B., Nelson, W.B., Powers, S.K., Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production (2009) Free Radic Biol Med., 46, pp. 842-850;
Whidden, M.A., Smuder, A.J., Wu, M., Hudson, M.B., Nelson, W.B., Powers, S.K., Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm (2010) J Appl Physiol., 108, pp. 1376-1382;
Grimble, R.F., Nutrition antioxidants and the modulation of inflammation theory and practice (1994) New Horiz., 2, pp. 175-185;
Hammerman, C., Kaplan, M., Ischemia and reperfusion injury (1998) Clin Perinatol., 25, pp. 757-777;
Alonso de Vega, J.M., Diaz, J., Serrano, E., Caronell, L.F., Oxidative stress in critically ill patients with systemic inflammatory response syndrome (2002) Crit Care Med., 30, pp. 1782-1786;
Heyland, D.K., Dhaliwal, R., Suchner, U., Berger, M.M., Antioxidant nutrients: a systemic review of trace elements and vitamins in the critically ill patient (2005) Intensive Care Med., 31, pp. 327-337;
Visser, J., Labadarios, D., Blaauw, R., Micronutrient supplementation for critically ill adults: a systematic review and meta-analysis (2011) Nutrition., 27, pp. 745-758;
Reddell, L., Cotton, B.A., Antioxidant and micronutrient supplementation in critically ill trauma patients (2012) Curr Opin Clin Nutr Metab Care., 15, pp. 181-187;
Manzanares, W., Dhaliwal, R., Jiang, X., Murch, L., Heyland, D.K., Antioxidant micronutrients in the critically ill: a systematic review and meta-analysis (2012) Crit Care., 16, p. R66;
Howe, K., Clochesy, J., Politis, J., Goldstein, L., Owen, H., Clinical trial design considerations: a comparison of enteral feeding volume ordered versus delivered (2004) Am J Crit Care., 13, p. 358;
Nathens, A.V., Neff, M.J., Jurkovich, G.J., Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients (2002) Ann Surg., 236, pp. 814-822;
Metnitz, P.G.H., Bartens, C., Fischer, M., Fridrich, P., Steltzer, H., Druml, W., Antioxidant status in patients with acute respiratory distress syndrome (1999) Intensive Care Med., 25, pp. 180-185;
Borrelli, E., Roux-Lombard, P., Grau, G.E., Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk (1996) Crit Care Med., 24, pp. 392-397;
Schorah, C.H., Downing, C., Piripitsi, A., Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients (1996) Am J Clin Nutr., 63, pp. 760-765;
Richard, C., Lemonnier, F., Thibault, M., Couturier, M., Auzepy, P., Vitamin E deficiency and lipid peroxidation during adult respiratory distress syndrome (1990) Crit Care Med., 18, pp. 4-6;
Bentrand, E., Pincemail, J., Hanique, G., Differences in tocopherol lipid ratios in ARDS and non-ARDS patients (1989) Intensive Care Med., 15, pp. 87-93;
de Vega, A., Diaz, J., Serrano, E., Carbonell, L.F., Plasma redox status relates to severity in critically ill patients (2000) Crit Care Med., 28, pp. 1812-1814;
Goode, H.F., Cowley, H.C., Walker, B.E., Howdle, P.D., Webster, N.R., Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction (1995) Crit Care Med., 23, pp. 646-651;
Preiser, J.C., Van Gossum, A., Berre, J., Vincent, J.L., Carpentier, Y., Enteral feeding with a solution enriched with antioxidant vitamins A, C, and E enhances the resistance to oxidative stress (2000) Crit Care Med., 28, pp. 3828-3832;
Pontes-Arruda, A., Albuquerque Aragao, A.F., Deusdara Albuquerque, J., Effects of enteral feeding with eicosapentaenoic acid, g-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock (2006) Crit Care Med, 34, pp. 2325-2333;
Miller, E.R., III, Pastor-Barriuso, R., Dalal, D., Riemersma, R.A., Appel, L.J., Guallar, E., Meta-analysis: high dose vitamin E supplementation may increase all-cause mortality (2005) Ann Intern Med., 142, pp. 37-46;
Szakmany, T., Hauser, B., Radermacher, P., N-acetylcysteine for sepsis and systemic inflammatory response in adults (2012) Cochrane Anaesth., 9, p. CD006616