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Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors
Journal article   Peer reviewed

Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors

Eric Wang, Xiaoli Mi, Meghan C Thompson, Skye Montoya, Ryan Q Notti, Jumana Afaghani, Benjamin H Durham, Alex Penson, Matthew T Witkowski, Sydney X Lu, …
The New England journal of medicine, Vol.386(8), pp.735-743
2022-02-24
PMID: 35196427

Abstract

Hematology Leukemia Lymphoma Oncology Treatments in Oncology
In nine patients with chronic lymphocytic leukemia that responded to the noncovalent BTK inhibitor pirtobrutinib and then developed resistance, analysis revealed a number of new mutations in the BTK kinase domain and occasional mutations in downstream PLCγ2. Despite the inactivity of BTK, alternative pathways of B-cell–receptor signaling were evident.

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Citation topics
1 Clinical & Life Sciences
1.130 Lymphomas
1.130.1170 Chronic Lymphocytic Leukemia
Web Of Science research areas
Hematology
ESI research areas
Clinical Medicine

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