Mesenchymal Stem Cell Therapy in Ischemic Stroke: A Meta-analysis of Preclinical Studies

Deepaneeta Sarmah; Vishal Agrawal; Pallavi Rane; Shashikala Bhute; Mitsuyoshi Watanabe; Kiran Kalia; Zhumur Ghosh; Kunjan R Dave; Dileep R Yavagal; Pallab Bhattacharya

doi:10.1002/cpt.927

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Mesenchymal Stem Cell Therapy in Ischemic Stroke: A Meta-analysis of Preclinical Studies

Journal article

Peer reviewed

Mesenchymal Stem Cell Therapy in Ischemic Stroke: A Meta-analysis of Preclinical Studies

Deepaneeta Sarmah, Vishal Agrawal, Pallavi Rane, Shashikala Bhute, Mitsuyoshi Watanabe, Kiran Kalia, Zhumur Ghosh, Kunjan R Dave, Dileep R Yavagal and Pallab Bhattacharya

Clinical pharmacology and therapeutics, Vol.103(6), pp.990-998

2018-06

DOI: https://doi.org/10.1002/cpt.927

PMID: 29090465

Abstract

Numerous preclinical studies have been carried out using mesenchymal stem cells (MSCs) therapy for ischemic stroke. The purpose of the present meta-analysis is to review the quality of preclinical studies. In all, 4,361 articles were identified, out of which 64 studies were included (excluding in vitro studies). The results were obtained across species, route, and time of administration, immunogenicity, and doses. The median quality score 4.90/10, confidence interval 95%, and large effect size were observed, which strongly supports the translation potential of MSC therapy for ischemic stroke.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.102 Stem Cell Research; 1.102.110 Mesenchymal Stem Cells
Web Of Science research areas: Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology

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Title: Mesenchymal Stem Cell Therapy in Ischemic Stroke: A Meta-analysis of Preclinical Studies
Creators: Deepaneeta Sarmah - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
Vishal Agrawal - Department of Medical Devices, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
Pallavi Rane - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
Shashikala Bhute - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
Mitsuyoshi Watanabe - Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA
Kiran Kalia - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
Zhumur Ghosh - Department of Bioinformatics, Bose Institute, Kolkata, India
Kunjan R Dave - Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA
Dileep R Yavagal - Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA
Pallab Bhattacharya - Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Publication Details: Clinical pharmacology and therapeutics, Vol.103(6), pp.990-998
Academic Unit: Miller School of Medicine; UMMG Department of Neurology
Language: English
Resource Type: Journal article
PMID: 29090465
Record Identifier: 991031598355802976