Metabolic Syndrome and Neurocognition Among Diverse Middle-Aged and Older Hispanics/Latinos: HCHS/SOL Results

Hector M González; Wassim Tarraf; Priscilla Vásquez; Ashley H Sanderlin; Natalya I Rosenberg; Sonia Davis; Carlos J Rodríguez; Linda C Gallo; Bharat Thyagarajan; Martha Daviglus; Tasneem Khambaty; Jianwen Cai; Neil Schneiderman

doi:10.2337/dc17-1896

Back

Metabolic Syndrome and Neurocognition Among Diverse Middle-Aged and Older Hispanics/Latinos: HCHS/SOL Results

Journal article

Open access

Peer reviewed

Metabolic Syndrome and Neurocognition Among Diverse Middle-Aged and Older Hispanics/Latinos: HCHS/SOL Results

Hector M González, Wassim Tarraf, Priscilla Vásquez, Ashley H Sanderlin, Natalya I Rosenberg, Sonia Davis, Carlos J Rodríguez, Linda C Gallo, Bharat Thyagarajan, Martha Daviglus, …

Diabetes care, Vol.41(7), pp.1501-1509

2018-07

DOI: https://doi.org/10.2337/dc17-1896

PMCID: PMC6014545

PMID: 29716895

Abstract

Ethnic Groups - statistics & numerical data

Cross-Sectional Studies

Aging - ethnology

Humans

Middle Aged

Aging - psychology

Hispanic Americans - statistics & numerical data

Male

Ethnic Groups - psychology

Executive Function - physiology

Hispanic Americans - psychology

Metabolic Syndrome - complications

Young Adult

Cognition Disorders - complications

Metabolic Syndrome - ethnology

Adolescent

Cognition - physiology

Adult

Female

Aged

Cognition Disorders - ethnology

Aging - metabolism

Metabolic Syndrome - psychology

Hispanics/Latinos have the highest risks for metabolic syndrome (MetS) in the U.S. and are also at increased risk for Alzheimer disease. In this study, we examined associations among neurocognitive function, MetS, and inflammation among diverse middle-aged and older Hispanics/Latinos. Cross-sectional data (2008-2011) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analyzed to examine associations between neurocognition and MetS among diverse Hispanics/Latinos ( = 9,136; aged 45-74 years). MetS status was associated with lower global neurocognition, mental status, verbal learning and memory, verbal fluency, and executive function. Age significantly modified the associations between MetS and learning and memory measures. Significant associations between MetS and neurocognition were observed among middle-aged Hispanics/Latinos, and all associations remained robust to additional covariates adjustment. We found that MetS was associated with lower neurocognitive function, particularly in midlife. Our findings support and extend current hypotheses that midlife may be a particularly vulnerable developmental period for unhealthy neurocognitive aging.

Files and links (1)

url

https://doi.org/10.2337/dc17-1896View

Published (Version of record) Open

Metrics

7 Record Views

14 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Endocrinology & Metabolism
ESI research areas: Clinical Medicine

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Metabolic Syndrome and Neurocognition Among Diverse Middle-Aged and Older Hispanics/Latinos: HCHS/SOL Results
Creators: Hector M González - Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, CA hectorgonzalez@ucsd.edu
Wassim Tarraf - Institute of Gerontology and Department of Healthcare Sciences, Wayne State University, Detroit, MI
Priscilla Vásquez - Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, CA
Ashley H Sanderlin - Section of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC
Natalya I Rosenberg - Institute for Minority Health Research, College of Medicine, University of Illinois at Chicago, Chicago, IL
Sonia Davis - Collaborative Studies Coordinating Center, Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC
Carlos J Rodríguez - Departments of Medicine and Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC
Linda C Gallo - Institute for Behavioral and Community Health and Graduate School of Public Health, San Diego State University, San Diego, CA
Bharat Thyagarajan - Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center Fairview, Minneapolis, MN
Martha Daviglus - Institute for Minority Health Research, College of Medicine, University of Illinois at Chicago, Chicago, IL
Tasneem Khambaty - Department of Psychology, University of Maryland, Baltimore County, Baltimore, MD
Jianwen Cai - Collaborative Studies Coordinating Center, Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC
Neil Schneiderman - Department of Psychology, University of Miami, Coral Gables, FL
Publication Details: Diabetes care, Vol.41(7), pp.1501-1509
Publisher: United States
Grant note: N01HC65235 / NHLBI NIH HHS P30 DK111022 / NIDDK NIH HHS P50 AG005131 / NIA NIH HHS R01 AG048642 / NIA NIH HHS N01HC65233 / NHLBI NIH HHS RF1 AG054548 / NIA NIH HHS N01HC65234 / NHLBI NIH HHS N01HC65236 / NHLBI NIH HHS P30 AG053760 / NIA NIH HHS N01HC65237 / NHLBI NIH HHS
Academic Unit: Miller School of Medicine; College of A&S; UMMG Department of Pathology; A&S - Psychology
Language: English
Resource Type: Journal article
PMID: 29716895
PMCID: PMC6014545
Record Identifier: 991031578548902976