Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

A. C Riggs; E BERNAL-MIZRACHI; M Ohsugi; J Wasson; S Fatrai; C Welling; J Murray; R. E Schmidt; P. L Herrera; M. A Permutt

doi:10.1007/s00125-005-1947-4

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Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

Journal article

Open access

Peer reviewed

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

A. C Riggs, E BERNAL-MIZRACHI, M Ohsugi, J Wasson, S Fatrai, C Welling, J Murray, R. E Schmidt, P. L Herrera and M. A Permutt

Diabetologia, Vol.48(11), pp.2313-2321

2005

DOI: https://doi.org/10.1007/s00125-005-1947-4

PMID: 16215705

Abstract

Biological and medical sciences

Complex syndromes

Diabetes. Impaired glucose tolerance

Endocrine pancreas. Apud cells (diseases)

Endocrinopathies

Etiopathogenesis. Screening. Investigations. Target tissue resistance

Medical genetics

Medical sciences

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis; 1.25.1406 Unfolded Protein Response
Web Of Science research areas: Endocrinology & Metabolism
ESI research areas: Clinical Medicine

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Title: Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis
Creators: A. C Riggs - Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8127, St Louis, MO 63110-1010, United States
E BERNAL-MIZRACHI - Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8127, St Louis, MO 63110-1010, United States
M Ohsugi - Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8127, St Louis, MO 63110-1010, United States
J Wasson - Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8127, St Louis, MO 63110-1010, United States
S Fatrai - Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8127, St Louis, MO 63110-1010, United States
C Welling - Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8127, St Louis, MO 63110-1010, United States
J Murray - Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8127, St Louis, MO 63110-1010, United States
R. E Schmidt - Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, United States
P. L Herrera - Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
M. A Permutt - Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8127, St Louis, MO 63110-1010, United States
Publication Details: Diabetologia, Vol.48(11), pp.2313-2321
Publisher: Springer
Academic Unit: Miller School of Medicine; UMMG Dept of Medicine - Endocrinology, Diabetes & Metabolism
Language: English
Resource Type: Journal article
PMID: 16215705
Record Identifier: 991031613718102976