Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy

Deepaneeta Sarmah; Harpreet Kaur; Jackson Saraf; Kanchan Vats; Kanta Pravalika; Madhuri Wanve; Kiran Kalia; Anupom Borah; Akhilesh Kumar; Xin Wang; Dileep R Yavagal; Kunjan R Dave; Pallab Bhattacharya

doi:10.1007/s12975-018-0642-y

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Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy

Journal article

Peer reviewed

Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy

Deepaneeta Sarmah, Harpreet Kaur, Jackson Saraf, Kanchan Vats, Kanta Pravalika, Madhuri Wanve, Kiran Kalia, Anupom Borah, Akhilesh Kumar, Xin Wang, …

Translational stroke research, Vol.10(2), pp.121-136

2018-06-20

DOI: https://doi.org/10.1007/s12975-018-0642-y

PMID: 29926383

Abstract

Neuroprotection

Mitochondria

Reactive oxygen species

Stroke

Extracellular vesicles

Tunnelling nanotubes

Cell fusion

Stroke is a debilitating condition which is also the second leading cause of death and disability worldwide. Despite the benefits and promises shown by numerous neuroprotective agents in animal stroke models, their clinical translation has not been a complete success. Hence, search for treatment options have directed researchers towards utilising stem cells. Mitochondria has a major involvement in the pathophysiology of stroke and a number of other conditions. Stem cells have shown the ability to transfer mitochondria to the damaged cells and to help revive cell energetics in the recipient cell. The present review discusses how stem cells could be employed to protect neurons and mitochondria in stroke and also the various mechanisms involved in neuroprotection.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.197 Molecular & Cell Biology - Mitochondria; 1.197.564 Mitochondrial DNA
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior

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Details

Title: Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy
Creators: Deepaneeta Sarmah - Department or Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India
Harpreet Kaur - Department or Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India
Jackson Saraf - Department or Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India
Kanchan Vats - Department or Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India
Kanta Pravalika - Department or Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India
Madhuri Wanve - Department or Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India
Kiran Kalia - Department or Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India
Anupom Borah - Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, Assam, India
Akhilesh Kumar - Department of Botany, Banaras Hindu University, Varanasi, India
Xin Wang - Department of Neurosurgery, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA
Dileep R Yavagal - Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA
Kunjan R Dave - Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA
Pallab Bhattacharya - Department or Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India. pallab.bhu@gmail.com
Publication Details: Translational stroke research, Vol.10(2), pp.121-136
Publisher: United States
Grant note: SB/YS/LS-196/2014 / Science and Engineering Research Board
Academic Unit: Miller School of Medicine; UMMG Department of Neurology
Language: English
Resource Type: Journal article
PMID: 29926383
Record Identifier: 991031561861402976