Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems

Ru Wen; Afoma C Umeano; Lily Francis; Nivita Sharma; Smanla Tundup; Shanta Dhar

doi:10.3390/vaccines4020018

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Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems

Journal article

Open access

Peer reviewed

Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems

Ru Wen, Afoma C Umeano, Lily Francis, Nivita Sharma, Smanla Tundup and Shanta Dhar

Vaccines (Basel), Vol.4(2), p.18

2016-06-01

DOI: https://doi.org/10.3390/vaccines4020018

PMCID: PMC4931635

PMID: 27258316

Abstract

antigen delivery

vaccine

nanoparticles

mitochondria targeting

Vaccination is one of the most popular technologies in disease prevention and eradication. It is promising to improve immunization efficiency by using vectors and/or adjuvant delivery systems. Nanoparticle (NP)-based delivery systems have attracted increasing interest due to enhancement of antigen uptake via prevention of vaccine degradation in the biological environment and the intrinsic immune-stimulatory properties of the materials. Mitochondria play paramount roles in cell life and death and are promising targets for vaccine delivery systems to effectively induce immune responses. In this review, we focus on NPs-based delivery systems with surfaces that can be manipulated by using mitochondria targeting moieties for intervention in health and disease.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.358 Dendritic Cells
Web Of Science research areas: Immunology; Medicine, Research & Experimental
ESI research areas: Immunology

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Title: Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems
Creators: Ru Wen - NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. soso2012@uga.edu
Afoma C Umeano - NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. aumeano@uga.edu
Lily Francis - NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. lgf39148@uga.edu
Nivita Sharma - NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. nivita.sharma97@uga.edu
Smanla Tundup - School of Medicine, Department of Pulmonary and Critical Care, University of Virginia, Charlottesville, WV 22908, USA. st2vk@virginia.edu
Shanta Dhar - NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. shanta@uga.edu
Publication Details: Vaccines (Basel), Vol.4(2), p.18
Grant note: R01 NS093314 / NINDS NIH HHS R56 HL121392 / NHLBI NIH HHS
Academic Unit: Miller School of Medicine; Biochemistry & Molecular Biology Research
Language: English
Resource Type: Journal article
PMID: 27258316
PMCID: PMC4931635
Record Identifier: 991031598417502976