Modification of pentobarbital effects by natural and synthetic polypeptides: Dissociation of brain and pituirary effects

Arthur J Prange; George R Breese; Gloria D Jahnke; Billy R Martin; Barrett R Cooper; Jerry M Cott; Ian C Wilson; Lacoe B Alltop; Morris A Lipton; Garth Bissette; Charles B Nemeroff; Peter T Loosen

doi:10.1016/0024-3205(75)90300-8

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Modification of pentobarbital effects by natural and synthetic polypeptides: Dissociation of brain and pituirary effects

Journal article

Peer reviewed

Modification of pentobarbital effects by natural and synthetic polypeptides: Dissociation of brain and pituirary effects

Arthur J Prange, George R Breese, Gloria D Jahnke, Billy R Martin, Barrett R Cooper, Jerry M Cott, Ian C Wilson, Lacoe B Alltop, Morris A Lipton, Garth Bissette, …

Life sciences (1973), Vol.16(12), pp.1907-1913

1975

DOI: https://doi.org/10.1016/0024-3205(75)90300-8

Abstract

Thyrotropin releasing hormone (TRH) antagonizes pentobarbital sedation and hypothermia; somatotropin release inhibiting factor amplifies them. Other hypothalamic polypeptide releasing factors, Substance P and a variety of amino acids are ineffective. Three congeners of TRH antagonize pentobarbital; one amplifies it. The potencies of congeners as pentobarbital antagonists are unrelated to their potencies as pituitary thyrotropin releasers.

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Details

Title: Modification of pentobarbital effects by natural and synthetic polypeptides: Dissociation of brain and pituirary effects
Creators: Arthur J Prange - Departments of Psychiatry and Pharmacology, Biological Sciences Research Center of the Child Development Institute University of North Carolina School of Medicine Chapel Hill, North Carolina 27514, USA
George R Breese - Division of Research, North Carolina Department of Mental Health Raleigh, North Carolina 27611, USA
Gloria D Jahnke - Division of Research, North Carolina Department of Mental Health Raleigh, North Carolina 27611, USA
Billy R Martin - Division of Research, North Carolina Department of Mental Health Raleigh, North Carolina 27611, USA
Barrett R Cooper - Division of Research, North Carolina Department of Mental Health Raleigh, North Carolina 27611, USA
Jerry M Cott - Division of Research, North Carolina Department of Mental Health Raleigh, North Carolina 27611, USA
Ian C Wilson - Departments of Psychiatry and Pharmacology, Biological Sciences Research Center of the Child Development Institute University of North Carolina School of Medicine Chapel Hill, North Carolina 27514, USA
Lacoe B Alltop - Departments of Psychiatry and Pharmacology, Biological Sciences Research Center of the Child Development Institute University of North Carolina School of Medicine Chapel Hill, North Carolina 27514, USA
Morris A Lipton - Division of Research, North Carolina Department of Mental Health Raleigh, North Carolina 27611, USA
Garth Bissette - Division of Research, North Carolina Department of Mental Health Raleigh, North Carolina 27611, USA
Charles B Nemeroff - Division of Research, North Carolina Department of Mental Health Raleigh, North Carolina 27611, USA
Peter T Loosen - Division of Research, North Carolina Department of Mental Health Raleigh, North Carolina 27611, USA
Publication Details: Life sciences (1973), Vol.16(12), pp.1907-1913
Publisher: Elsevier Inc
Academic Unit: UMMG Dept of Psychiatry & Behavioral Sciences
Language: English
Resource Type: Journal article
Record Identifier: 991031613928602976