Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin

Andrea Marzi; Daniel A Mitchell; Chawaree Chaipan; Tanja Fisch; Robert W Doms; Mary Carrington; Ronald C Desrosiers; Stefan Pöhlmann

doi:10.1016/j.virol.2007.07.004

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Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin

Journal article

Open access

Peer reviewed

Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin

Andrea Marzi, Daniel A Mitchell, Chawaree Chaipan, Tanja Fisch, Robert W Doms, Mary Carrington, Ronald C Desrosiers and Stefan Pöhlmann

Virology (New York, N.Y.), Vol.368(2), pp.322-330

2007

DOI: https://doi.org/10.1016/j.virol.2007.07.004

PMID: 17659761

Abstract

SIV

Attachment

Antibody

DC-SIGN

MBL

Neutralization

The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV-1
Web Of Science research areas: Virology
ESI research areas: Microbiology

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Details

Title: Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin
Creators: Andrea Marzi - Institute for Clinical and Molecular Virology, University Hospital Erlangen, 91054 Erlangen, Germany
Daniel A Mitchell - Clinical Sciences Research Institute, Warwick Medical School, Coventry CV2 2DX, UK
Chawaree Chaipan - Institute for Clinical and Molecular Virology, University Hospital Erlangen, 91054 Erlangen, Germany
Tanja Fisch - Institute for Clinical and Molecular Virology, University Hospital Erlangen, 91054 Erlangen, Germany
Robert W Doms - Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Mary Carrington - Laboratory of Genomic Diversity, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702-1201, USA
Ronald C Desrosiers - New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P.O. Box 9102, Southborough, MA 01772-9102, USA
Stefan Pöhlmann - Institute for Clinical and Molecular Virology, University Hospital Erlangen, 91054 Erlangen, Germany
Publication Details: Virology (New York, N.Y.), Vol.368(2), pp.322-330
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 17659761
Record Identifier: 991031599974202976