Multiple Brain Networks Mediating Stimulus–Pain Relationships in Humans

Stephan Geuter; Elizabeth A Reynolds Losin; Mathieu Roy; Lauren Y Atlas; Liane Schmidt; Anjali Krishnan; Leonie Koban; Tor D Wager; Martin A Lindquist

doi:10.1093/cercor/bhaa048

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Multiple Brain Networks Mediating Stimulus–Pain Relationships in Humans

Journal article

Peer reviewed

Multiple Brain Networks Mediating Stimulus–Pain Relationships in Humans

Stephan Geuter, Elizabeth A Reynolds Losin, Mathieu Roy, Lauren Y Atlas, Liane Schmidt, Anjali Krishnan, Leonie Koban, Tor D Wager and Martin A Lindquist

Cerebral cortex (New York, N.Y. 1991), Vol.30(7), pp.4204-4219

2020-06-01

DOI: https://doi.org/10.1093/cercor/bhaa048

PMID: 32219311

Abstract

Abstract The brain transforms nociceptive input into a complex pain experience comprised of sensory, affective, motivational, and cognitive components. However, it is still unclear how pain arises from nociceptive input and which brain networks coordinate to generate pain experiences. We introduce a new high-dimensional mediation analysis technique to estimate distributed, network-level patterns that formally mediate the relationship between stimulus intensity and pain. We applied the model to a large-scale analysis of functional magnetic resonance imaging data (N = 284), focusing on brain mediators of the relationship between noxious stimulus intensity and trial-to-trial variation in pain reports. We identify mediators in both traditional nociceptive pathways and in prefrontal, midbrain, striatal, and default-mode regions unrelated to nociception in standard analyses. The whole-brain mediators are specific for pain versus aversive sounds and are organized into five functional networks. Brain mediators predicted pain ratings better than previous brain measures, including the neurologic pain signature (Wager et al. 2013). Our results provide a broader view of the networks underlying pain experience, as well as novel brain targets for interventions.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.43 Anesthesiology; 1.43.135 Neuropathic Pain
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior

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Details

Title: Multiple Brain Networks Mediating Stimulus–Pain Relationships in Humans
Creators: Stephan Geuter - Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA, Institute of Cognitive Science, University of Colorado Boulder, Boulder, CO, USA, Vorwerk International & Co. KmG, Zurich, Switzerland
Elizabeth A Reynolds Losin - Department of Psychology, University of Miami, Coral Gables, FL, USA
Mathieu Roy - Department of Psychology, McGill University, Montreal, Quebec, Canada
Lauren Y Atlas - National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, USA, National Center on Drug Abuse, National Institutes of Health, Bethesda, MD, USA, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Liane Schmidt - Control-Interoception-Attention Team, Institute du Cerveau et de la Moelle épinière, INSERM UMR 1127, CNRS UMR 7225, Sorbonne University, Paris, France
Anjali Krishnan - Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY, USA
Leonie Koban - Institute of Cognitive Science, University of Colorado Boulder, Boulder, CO, USA, Control-Interoception-Attention Team, Institute du Cerveau et de la Moelle épinière, INSERM UMR 1127, CNRS UMR 7225, Sorbonne University, Paris, France, Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA, Marketing Area, INSEAD, Fontainebleau, France
Tor D Wager - Institute of Cognitive Science, University of Colorado Boulder, Boulder, CO, USA, Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA, Presidential Cluster in Neuroscience and Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA
Martin A Lindquist - Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA
Publication Details: Cerebral cortex (New York, N.Y. 1991), Vol.30(7), pp.4204-4219
Academic Unit: College of A&S; A&S - Psychology
Language: English
Resource Type: Journal article
PMID: 32219311
Record Identifier: 991031576632602976