Abstract
The intricate process of wiring a neuronetwork requires a high degree of accuracy in the communication between pre‐ and post‐synaptic cells. While presynaptic cells have been widely recognized for their dynamic role in synaptic matchmaking, post‐synaptic cells have historically been overlooked as passive targets. Recent studies in the Drosophila embryonic neuromuscular system provide compelling evidence that post‐synaptic cells participate actively in the synaptogenic process. Endocytosis allows them to quickly modify the array of molecular cues they provide on their surfaces and the extension of dynamic filopodia allows post‐synaptic cells to engage in direct long‐distance communication. By making use of familiar cellular mechanisms such as endocytosis and filopodia formation, post‐synaptic cells may be able to communicate more effectively with potential synaptic partners.
