Multivalent Binding and Facilitated Diffusion Account for the Formation of the Grb2–Sos1 Signaling Complex in a Cooperative Manner

Caleb B McDonald; Jordan E Balke; Vikas Bhat; David C Mikles; Brian J Deegan; Kenneth L Seldeen; Amjad Farooq

doi:10.1021/bi3000534

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Multivalent Binding and Facilitated Diffusion Account for the Formation of the Grb2–Sos1 Signaling Complex in a Cooperative Manner

Journal article

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Peer reviewed

Multivalent Binding and Facilitated Diffusion Account for the Formation of the Grb2–Sos1 Signaling Complex in a Cooperative Manner

Caleb B McDonald, Jordan E Balke, Vikas Bhat, David C Mikles, Brian J Deegan, Kenneth L Seldeen and Amjad Farooq

Biochemistry (Easton), Vol.51(10), pp.2122-2135

2012-03-13

DOI: https://doi.org/10.1021/bi3000534

PMCID: PMC3303612

PMID: 22360309

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Citation topics: 1 Clinical & Life Sciences; 1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis; 1.25.1481 Noonan Syndrome
Web Of Science research areas: Biochemistry & Molecular Biology
ESI research areas: Biology & Biochemistry

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Title: Multivalent Binding and Facilitated Diffusion Account for the Formation of the Grb2–Sos1 Signaling Complex in a Cooperative Manner
Creators: Caleb B McDonald - Department of Biochemistry and Molecular Biology and USylvester Braman Family Breast Cancer Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida 33136, United States
Jordan E Balke - Department of Biochemistry and Molecular Biology and USylvester Braman Family Breast Cancer Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida 33136, United States
Vikas Bhat - Department of Biochemistry and Molecular Biology and USylvester Braman Family Breast Cancer Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida 33136, United States
David C Mikles - Department of Biochemistry and Molecular Biology and USylvester Braman Family Breast Cancer Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida 33136, United States
Brian J Deegan - Department of Biochemistry and Molecular Biology and USylvester Braman Family Breast Cancer Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida 33136, United States
Kenneth L Seldeen - Department of Biochemistry and Molecular Biology and USylvester Braman Family Breast Cancer Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida 33136, United States
Amjad Farooq - Department of Biochemistry and Molecular Biology and USylvester Braman Family Breast Cancer Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida 33136, United States
Publication Details: Biochemistry (Easton), Vol.51(10), pp.2122-2135
Academic Unit: Miller School of Medicine; Biochemistry & Molecular Biology Research
Language: English
Resource Type: Journal article
PMID: 22360309
PMCID: PMC3303612
Record Identifier: 991031561501302976