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Murine Models Demonstrate Distinct Vasculogenic and Cardiomyogenic cKit+ Lineages in the Heart
Journal article   Open access  Peer reviewed

Murine Models Demonstrate Distinct Vasculogenic and Cardiomyogenic cKit+ Lineages in the Heart

Konstantinos E Hatzistergos and Joshua M Hare
Circulation research, Vol.118(3), pp.382-387
2016-02-05
PMCID: PMC4746002
PMID: 26846638

Abstract

Endothelial Cells - metabolism Heart - embryology Coronary Vessels - embryology Genotype Mice, Transgenic Proto-Oncogene Proteins c-kit - metabolism Coronary Vessels - metabolism Morphogenesis Cell Lineage Phenotype Animals Myocytes, Cardiac - metabolism Proto-Oncogene Proteins c-kit - genetics Cell Differentiation
After 2 recent genetic studies in mice addressing the developmental origins and regenerative activity of cardiac cKit+ cells, 2 additional reports by Sultana et al and Liu et al provide further information on the expression of cKit in the embryonic and adult hearts. Here, we synthesize the findings from the 4 distinct cKit models to gain insights into the biology of this important cell type.
url
https://doi.org/10.1161/CIRCRESAHA.115.308061View
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Citation topics
1 Clinical & Life Sciences
1.102 Stem Cell Research
1.102.110 Mesenchymal Stem Cells
Web Of Science research areas
Cardiac & Cardiovascular Systems
Hematology
Peripheral Vascular Disease
ESI research areas
Clinical Medicine

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