NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN

A Grossman; L Perry; A.V Schally; LesleyH Rees; A.C Nieuwenhuyzen Kruseman; Susan Tomlin; D.H Coy; Ana-Maria Comaru-Schally; G.M Besser

doi:10.1016/S0140-6736(82)91929-8

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NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN

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NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN

A Grossman, L Perry, A.V Schally, LesleyH Rees, A.C Nieuwenhuyzen Kruseman, Susan Tomlin, D.H Coy, Ana-Maria Comaru-Schally and G.M Besser

The Lancet (British edition), Vol.319(8278), pp.921-922

1982-04-24

DOI: https://doi.org/10.1016/S0140-6736(82)91929-8

Abstract

A synthetic preparation of the 41-aminoacid-residue peptide recently isolated from ovine hypothalami and characterised corticotropin-releasing factor (CRF), has been given intravenously to six normal men. 100 μg synthetic CRF caused rises in circulating levels of adrenocorticotropic hormone (ACTH) and cortisol but had no effect on levels of prolactin, growth hormone, thyrotropin, or gonadotropins. Its specific action suggests that it, or a related peptide, may be a CRF in man, and it may provide the basis for a new clinical test of pituitary ACTH reserve.

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Title: NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN
Creators: A Grossman - Departments of Endocrinology, Chemical Endocrinology, and Reproductive Physiology, St Bartholomew's Hospital, London, United Kingdon
L Perry - Departments of Endocrinology, Chemical Endocrinology, and Reproductive Physiology, St Bartholomew's Hospital, London, United Kingdon
A.V Schally - Departments of Endocrinology, Chemical Endocrinology, and Reproductive Physiology, St Bartholomew's Hospital, London, United Kingdon
LesleyH Rees - Departments of Endocrinology, Chemical Endocrinology, and Reproductive Physiology, St Bartholomew's Hospital, London, United Kingdon
A.C Nieuwenhuyzen Kruseman - Departments of Endocrinology, Chemical Endocrinology, and Reproductive Physiology, St Bartholomew's Hospital, London, United Kingdon
Susan Tomlin - Departments of Endocrinology, Chemical Endocrinology, and Reproductive Physiology, St Bartholomew's Hospital, London, United Kingdon
D.H Coy - Departments of Endocrinology, Chemical Endocrinology, and Reproductive Physiology, St Bartholomew's Hospital, London, United Kingdon
Ana-Maria Comaru-Schally - Departments of Endocrinology, Chemical Endocrinology, and Reproductive Physiology, St Bartholomew's Hospital, London, United Kingdon
G.M Besser - Departments of Endocrinology, Chemical Endocrinology, and Reproductive Physiology, St Bartholomew's Hospital, London, United Kingdon
Publication Details: The Lancet (British edition), Vol.319(8278), pp.921-922
Publisher: Elsevier Ltd
Academic Unit: Miller School of Medicine; UMMG Department of Pathology
Language: English
Resource Type: Journal article
Record Identifier: 991031614736402976