NMNAT: It's an NAD + synthase… It's a chaperone… It's a neuroprotector

Jennifer M Brazill; Chong Li; Yi Zhu; R Grace Zhai

doi:10.1016/j.gde.2017.03.014

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NMNAT: It's an NAD + synthase… It's a chaperone… It's a neuroprotector

Journal article

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NMNAT: It's an NAD + synthase… It's a chaperone… It's a neuroprotector

Jennifer M Brazill, Chong Li, Yi Zhu and R Grace Zhai

Current opinion in genetics & development, Vol.44, pp.156-162

2017-06

DOI: https://doi.org/10.1016/j.gde.2017.03.014

PMCID: PMC5515290

PMID: 28445802

Abstract

Amide Synthases - genetics

Humans

Molecular Chaperones - genetics

NAD - biosynthesis

Neurodegenerative Diseases - enzymology

Neurodegenerative Diseases - genetics

Neurodegenerative Diseases - pathology

Neurons - enzymology

Neurons - pathology

Nicotinamide-Nucleotide Adenylyltransferase - genetics

Nicotinamide mononucleotide adenylyl transferases (NMNATs) are a family of highly conserved proteins indispensable for cellular homeostasis. NMNATs are classically known for their enzymatic function of catalyzing NAD synthesis, but also have gained a reputation as essential neuronal maintenance factors. NMNAT deficiency has been associated with various human diseases with pronounced consequences on neural tissues, underscoring the importance of the neuronal maintenance and protective roles of these proteins. New mechanistic studies have challenged the role of NMNAT-catalyzed NAD production in delaying Wallerian degeneration and have specified new mechanisms of NMNAT's chaperone function critical for neuronal health. Progress in understanding the regulation of NMNAT has uncovered a neuronal stress response with great therapeutic promise for treating various neurodegenerative conditions.

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Citation topics: 1 Clinical & Life Sciences; 1.253 Nerve Disorders; 1.253.1134 Nerve Regeneration
Web Of Science research areas: Cell Biology; Genetics & Heredity
ESI research areas: Molecular Biology & Genetics

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Details

Title: NMNAT: It's an NAD + synthase… It's a chaperone… It's a neuroprotector
Creators: Jennifer M Brazill - Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, United States
Chong Li - Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, United States
Yi Zhu - Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, United States
R Grace Zhai - Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, United States. Electronic address: gzhai@miami.edu
Publication Details: Current opinion in genetics & development, Vol.44, pp.156-162
Grant note: R56 NS064269 / NINDS NIH HHS R01 NS064269 / NINDS NIH HHS
Academic Unit: Miller School of Medicine; Molecular and Cellular Pharmacology Research
Language: English
Resource Type: Journal article
PMID: 28445802
PMCID: PMC5515290
Record Identifier: 991031614077402976