Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope Ⓡ -Global Registry for Emerging Fungal Infections

Jon Salmanton-García; Philipp Koehler; Anupma Kindo; Iker Falces-Romero; Julio García-Rodríguez; Zdeněk Ráčil; Sharon C-A Chen; Nikolai Klimko; Guillaume Desoubeaux; George R Thompson, , III; Miguel-Ángel Benítez-Peñuela; José-Yesid Rodríguez; Donald C Sheppard; Martin Hoenigl; Yohann Le Govic; Hamid Badali; John W Baddley; Jagdish Chander; Paul R Ingram; Diana L Pakstis; Sibylle C Mellinghoff; Serkan Atıcı; Simone Cesaro; Arunaloke Chakrabarti; Damien Dupont; Gloria M González; Lóránt Hatvani; Raoul Herbrecht; Galina Klyasova; Cornelia Lass-Flörl; Mihai Mareș; Kathleen Mullane; Donald C Vinh; Hilmar Wisplinghoff; Michaela Lackner; Oliver A Cornely; Danila Seidel

doi:10.1016/j.jinf.2020.08.015

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Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope Ⓡ -Global Registry for Emerging Fungal Infections

Journal article

Peer reviewed

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope Ⓡ -Global Registry for Emerging Fungal Infections

Jon Salmanton-García, Philipp Koehler, Anupma Kindo, Iker Falces-Romero, Julio García-Rodríguez, Zdeněk Ráčil, Sharon C-A Chen, Nikolai Klimko, Guillaume Desoubeaux, George R Thompson, , III, …

The Journal of infection, Vol.81(5), pp.802-815

2020-11

DOI: https://doi.org/10.1016/j.jinf.2020.08.015

PMID: 32798532

Abstract

Mycoses - epidemiology

Invasive Fungal Infections - epidemiology

Invasive Fungal Infections - drug therapy

Humans

Mycoses - drug therapy

Registries

Antifungal Agents - therapeutic use

Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Extremely rare IFI collected in the FungiScope registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope . Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.148 Medical Mycology; 1.148.94 Candida Albicans
Web Of Science research areas: Infectious Diseases
ESI research areas: Immunology

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Title: Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope Ⓡ -Global Registry for Emerging Fungal Infections
Creators: Jon Salmanton-García - University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Herderstrasse 52-54, 50931 Cologne, Germany. Electronic address: jon.salmanton-garcia@uk-koeln.de
Philipp Koehler - University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Herderstrasse 52-54, 50931 Cologne, Germany; University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany
Anupma Kindo - Department of Microbiology, Sri Ramachandra Medical College and Research Institute, SRIHER, Chennai, India
Iker Falces-Romero - Clinical Microbiology and Parasitology Department, University Hospital La Paz, Madrid, Spain
Julio García-Rodríguez - Clinical Microbiology and Parasitology Department, University Hospital La Paz, Madrid, Spain
Zdeněk Ráčil - Department of Internal Medicine-Hematology and Oncology, Masaryk University, Brno, Czech Republic; University Hospital Brno, Brno, Czech Republic; Institute of Hematology and Blood Transfusion, Prague, Czech Republic
Sharon C-A Chen - Centre for Diseases and Microbiology Laboratory Services, ICPMR, New South Wales Health Pathology, Westmead Hospital, Sydney, NSW, Australia; The University of Sydney, Westmead, Sydney, NSW, Australia
Nikolai Klimko - Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation
Guillaume Desoubeaux - Parasitologie - Mycologie - Médecine Tropicale, CHU de Tours, France; Centre d'Etude des Pathologies Respiratoires - Unité Inserm U1100, Université de Tours, Tours, France
George R Thompson, , III - Department of Internal Medicine Division of Infectious Diseases, University of California Davis Medical Center, Sacramento, CA, United States; Department of Medical Microbiology and Immunology, University of California Davis Medical Center, Sacramento, CA, United States
Miguel-Ángel Benítez-Peñuela - Center of Microbiological Research of Cesar (CIMCE), Rosario Pumarejo de López Hospital, Laura Daniela Clinic, Médicos Clinic LTDA, Valledupar, Colombia
José-Yesid Rodríguez - Center of Microbiological Research of Cesar (CIMCE), Rosario Pumarejo de López Hospital, Laura Daniela Clinic, Médicos Clinic LTDA, Valledupar, Colombia
Donald C Sheppard - Division of Infectious Diseases, Departments of Medicine, Microbiology and Immunology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Martin Hoenigl - Clinical and Translational Fungal-Working Group, University of California San Diego, La Jolla, CA, United States; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA, United States; ECMM Excellence Center for Clinical Mycology, Section of Infectious Diseases and Tropical Medicine and Division of Pulmonology, Medical University of Graz, Graz, Austria
Yohann Le Govic - Parasitology-Mycology Unit, University Hospital Center, Fort-de-France, Martinique, French West Indies
Hamid Badali - Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
John W Baddley - Department of Internal Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, AL, United States; Medical Service, Birmingham VA Medical Center, AL, United States; Institute for Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States
Jagdish Chander - Department of Microbiology, Government Medical College and Hospital, Chandigarh, India
Paul R Ingram - Department of Infectious Diseases, Royal Perth Hospital, Perth, WA, Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia
Diana L Pakstis - Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Palestine, State of, United States
Sibylle C Mellinghoff - University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Herderstrasse 52-54, 50931 Cologne, Germany
Serkan Atıcı - Department of Pediatrics, Division of Pediatric Infectious Disease, Okan University School of Medicine, Istanbul, Turkey
Simone Cesaro - Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata Verona, Italy
Arunaloke Chakrabarti - Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Research, Chandigarh, India
Damien Dupont - Institut des Agents Infectieux, Parasitologie Mycologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France; Integrative Physiology of the Brain Arousal Systems, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Lyon, France
Gloria M González - Department of Microbiology, School of Medicine, Universidad Autonóma de Nuevo León, Nuevo León, Mexico
Lóránt Hatvani - MTA-SZTE "Lendület" Mycobiome Research Group, Szeged, Hungary; Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary
Raoul Herbrecht - Department of Oncology and Hematology, Hôpitaux Universitaires de Strasbourg and Université de Strasbourg, Inserm, UMR-S1113/IRFAC, Strasbourg, France
Galina Klyasova - epartment of Clinical Microbiology, Mycology and Antibiotic Therapy, National Research Center for Hematology, Moscow, Russia
Cornelia Lass-Flörl - Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria
Mihai Mareș - Laboratory of Antimicrobial Chemotherapy, Ion Ionescu de la Brad University, Iași, Romania
Kathleen Mullane - Department of Medicine, Section of Infectious Diseases and Global Health, University of Chicago, Chicago, IL, United States
Donald C Vinh - Research Institute - McGill University Health Centre, Infectious Diseases and Immunity in Global Health Program, Montreal, QC, Canada
Hilmar Wisplinghoff - Wisplinghoff Laboratories, Cologne, Germany; Institute for Medical Microbiology, University of Cologne, Cologne, Germany; Institute for Virology and Microbiology, Witten/Herdecke University, Witten, Germany
Michaela Lackner - Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria
Oliver A Cornely - University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Herderstrasse 52-54, 50931 Cologne, Germany; German Centre for Infection Research (DZIF), partner site Bonn - Cologne, Cologne, Germany; Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
Danila Seidel - University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), Herderstrasse 52-54, 50931 Cologne, Germany. Electronic address: danila.seidel@uk.koeln.de
Publication Details: The Journal of infection, Vol.81(5), pp.802-815
Publisher: England
Language: English
Resource Type: Journal article
PMID: 32798532
Record Identifier: 991031575638602976